N'-chloro-4-(chloroamino)benzenecarboximidamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-chloro-4-(chloroamino)benzenecarboximidamide
• 化学式: C₇H₇Cl₂N₃
• 分子量: 204.05
• InChiKey: DAZVVHAPSIDTEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] PROCESS FOR THE MANUFACTURE OF 4-AMINOBENZOAMIDINE DIHYDROCHLORIDE<br/>[FR] PROCÉDÉ DE FABRICATION DE 4-AMINOBENZOAMIDINE DICHLORHYDRATE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2014064016A1

  公开（公告）日：2014-05-01

  The present invention relates to a process for the preparation of 4-aminobenzoamidine (4-AMBA) salts of general formula (I), preferably the salts thereof with hydrochloric or hydrobromic acid, particularly preferred the dichloride salt.

  本发明涉及一种制备4-氨基苯甲酰胺（4-AMBA）盐的方法，其一般式为（I），优选其与盐酸或溴酸的盐，特别优选二氯化物盐。
• [EN] METHOD FOR PRODUCING AMIDINE DERIVATIVES<br/>[FR] PROCÉDÉ DE PRODUCTION DE DÉRIVÉS D'AMIDINE
  申请人：BIOCRYST PHARM INC

  公开号：WO2016029216A2

  公开（公告）日：2016-02-25

  The invention provides methods and intermediates useful in the synthesis of a compound of formula (I): or a pharmaceutically acceptable salt, solvate, ester or prodrug thereof; wherein the variables are as defined herein.

  本发明提供了用于合成式(I)化合物的方法和中间体，或其药学上可接受的盐、溶剂和前药酯；其中变量如本文所定义。
• NOVEL PROCESS FOR THE MANUFACTURE OF 4-AMINOBENZOAMIDINE DIHYDROCHLORIDE
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20160297744A1

  公开（公告）日：2016-10-13

  The present invention relates to a process for the preparation of 4-aminobenzoamidine (4-AMBA) salts of general formula (I) preferably the salts thereof with hydrochloric or hydrobromic acid, particularly preferred the dichloride salt.
• Compositions and Uses of Amidine Derivatives
  申请人：BIOCRYST PHARMACEUTICALS, INC.

  公开号：US20170266172A1

  公开（公告）日：2017-09-21

  Use of a compound of formula (I): wherein A, X, Y, R 1 and R 2 as defined herein, in treating hereditary angioedema is disclosed. A composition containing the compounds, a polar organic solvent or a mixture thereof; and optionally a co-solvent, is also disclosed.
• US9399616B2
  申请人：——

  公开号：US9399616B2

  公开（公告）日：2016-07-26