2-Bromo-2-(3,5-dihydroxyphenyl)acetaldehyde

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Bromo-2-(3,5-dihydroxyphenyl)acetaldehyde
• 英文别名: 2-bromo-2-(3,5-dihydroxyphenyl)acetaldehyde
• 化学式: C₈H₇BrO₃
• 分子量: 231.04
• InChiKey: YXBJCKKFXFDDIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] INDOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS DNA METHYLATION MODULATORS<br/>[FR] DÉRIVÉS D'INDOLES, COMPOSITIONS PHARMACEUTIQUES CONTENANT DE TELS INDOLES ET LEUR UTILISATION EN TANT QUE MODULATEURS DE LA MÉTHYLATION DE L'ADN
  申请人：IKERCHEM S L

  公开号：WO2014072371A1

  公开（公告）日：2014-05-15

  The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer hematological malignancy, proliferative diseases, genetic diseases, neurological disorders and immunological disorders.

  本发明涉及公式(I)的化合物，以及它们的制备方法、包含它们的制药组合物，以及用于治疗和/或化学预防癌症、血液恶性肿瘤、增生性疾病、遗传疾病、神经系统疾病和免疫系统疾病的用途。
• INDOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS DNA METHYLATION MODULATORS
  申请人：Ikerchem, S.L.

  公开号：EP2917173A1

  公开（公告）日：2015-09-16
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：EP2958897A2

  公开（公告）日：2015-12-30
• [EN] COMPOUNDS USEFUL AS MODULATORS OF TRPM8<br/>[FR] COMPOSÉS UTILES COMME MODULATEURS DE TRPM8
  申请人：SENOMYX INC

  公开号：WO2014130582A2

  公开（公告）日：2014-08-28

  The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.