(3R)-3-(3-fluoro-4-phenylphenyl)butan-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3R)-3-(3-fluoro-4-phenylphenyl)butan-2-one
• 化学式: C₁₆H₁₅FO
• 分子量: 242.29
• InChiKey: NSQGOLBAOJUBSR-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same
  申请人：Yale University

  公开号：US20140302523A1

  公开（公告）日：2014-10-09

  The present invention includes compounds that are useful in perturbing or disrupting the function of a transmembrane or intracellular protein, whereby binding of a compound to the transmembrane or intracellular protein induces proteasomal degradation of the transmembrane or intracellular protein. The present invention further includes a method of inducing proteasomal degradation of a transmembrane or intracellular protein. The present invention further includes a method of identifying or validating a protein of interest as a therapeutic target for treatment of a disease state or condition.

  本发明包括一些化合物，这些化合物有助于扰乱或破坏跨膜或胞内蛋白的功能，其中化合物与跨膜或胞内蛋白的结合诱导跨膜或胞内蛋白的蛋白酶体降解。本发明还包括一种诱导跨膜或胞内蛋白的蛋白酶体降解的方法。本发明还包括一种鉴定或验证感兴趣蛋白作为治疗疾病状态或病情的治疗靶点的方法。
• METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBOXYLIC ACID ESTER
  申请人：Shiina Isamu

  公开号：US20140135520A1

  公开（公告）日：2014-05-15

  A method that manufacturers an optically active carboxylic acid ester at high yield and high enantioselectivity is provided. An optically active carboxylic acid ester is manufactured at high yield and high enantioselectivity by reacting a racemic carboxylic acid and a specific alcohol or phenol derivatives in a polar solvent having a dipole moment of 3.0 or higher in the presence of an acid anhydride and an asymmetric catalyst, esterifying one enantiomer of the racemic carboxylic acid at high selectivity, and increasing the amount of esterified carboxylic acid by racemizing the optically active carboxylic acid which is the other enantiomer not used in esterification.
• THE INHIBITION OF THE TOXIC EFFECTS OF ISLET AMYLOID FORMATION BY FLURBIPROFEN AND FLURBIPROFEN DERIVATIVES
  申请人：RALEIGH Daniel

  公开号：US20160038448A1

  公开（公告）日：2016-02-11

  The subject invention provides a method of reducing the presence of toxic intermediates of amyloidosis from islet amyloid polypeptide (IAPP) in a patient, comprising administering a compound to the patient a compound having the structure: (Formula 1) wherein R1 and R2 are each independently hydrogen, methyl, ethyl, propyl, butyl, pentyl, hexyl, or R1 and R2 are linked so as to form a cyclopropyl cyclobutyl, cyclopentyl, or cyclohexyl ring; wherein R3, R4, R5, R6 are each independently hydrogen, fluorine or chlorine; and wherein R7 is hydrogen, phenyl, fluorine, chlorine, bromine, hydroxyl, amine, carboxylic acid, C1-C6 alkyl carboxylate, amide, methyl, ethyl, butyl, pentyl, hexyl, or a pharmaceutically acceptable salt or ester thereof, so as to thereby reduce the presence of toxic intermediates of amyloidosis from islet amyloid polypeptide (IAPP) in the patient.
• US9315442B2
  申请人：——

  公开号：US9315442B2

  公开（公告）日：2016-04-19
• US9500653B2
  申请人：——

  公开号：US9500653B2

  公开（公告）日：2016-11-22