5-amino-N-[2-[[2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetyl]amino]ethyl]-2-hydroxybenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-amino-N-[2-[[2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetyl]amino]ethyl]-2-hydroxybenzamide
• 化学式: C₂₉H₂₈FN₃O₄S
• 分子量: 533.6
• InChiKey: RHLLOFAIKMHAQR-QRVIBDJDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  141
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF ACUTE INFLAMMATION<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT D'UNE INFLAMMATION AIGUË
  申请人：KANDULA MAHESH

  公开号：WO2014068461A2

  公开（公告）日：2014-05-08

  The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of acute inflammation may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of neuropathy, polyps and precancerous lesions in the colon, especially in association with familial adenomatous polyposis, cancer, Alzheimer's disease and pain.