4-[(3S,4R)-3-acetyl-4-(methylamino)pyrrolidin-1-yl]-4-oxobutanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 4-[(3S,4R)-3-acetyl-4-(methylamino)pyrrolidin-1-yl]-4-oxobutanoic acid
• 化学式: C₁₁H₁₈N₂O₄
• 分子量: 242.27
• InChiKey: RVAHKFBWZBOYNS-BDAKNGLRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.5
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  86.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• COMPOSITIONS COMPRISING GLUCAGON ANALOGS AND METHODS OF MAKING AND USING THE SAME
  申请人：Longevity Biotech, Inc.

  公开号：EP2694095B1

  公开（公告）日：2018-03-07
• Compositions Comprising Glucagon Analogs And Methods Of Making And Using The Same
  申请人：Shandler Scott

  公开号：US20140121154A1

  公开（公告）日：2014-05-01

  This invention relates to novel compositions comprising analogs of glucagon, wherein the analog comprises an α-amino acid and at least one β-amino acid. Administration of the compositions may be used for effecting treatment or prevention of a plurality of disease states caused by dysfunctional biochemical or biological pathways, including diabetes and other metabolic disorders. The compositions and methods of this invention are particularly useful to identify novel therapeutic modulators of in-vivo receptor activity with extended half-lives and relevant bioactivity as compared to the naturally translated polypeptides upon which the analogs are derived.
• US9790262B2
  申请人：——

  公开号：US9790262B2

  公开（公告）日：2017-10-17