2-(phenyldisulfanyl)ethyl N-aminocarbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(phenyldisulfanyl)ethyl N-aminocarbamate
• 化学式: C₉H₁₂N₂O₂S₂
• 分子量: 244.3
• InChiKey: LBAPGBQSWLOXIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Protein-Polymer-Drug Conjugates
  申请人：MERSANA THERAPEUTICS, INC.

  公开号：US20140134127A1

  公开（公告）日：2014-05-15

  A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L D -D, the protein based recognition-molecule being connected to the polymeric carrier by L P . Each occurrence of D is independently a therapeutic agent having a molecular weight ≦5 kDa. L D and L P are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

  本文提供了一种药物结合物。该结合物包括基于蛋白质的识别分子（PBRM）和多聚载体，该多聚载体被取代了一个或多个-LD-D，蛋白质基于识别分子通过LP连接到多聚载体上。D的每个出现都是分子量≦5 kDa的治疗剂。LD和LP是连接治疗剂和PBRM到多聚载体的连接剂。还披露了用于与PBRM结合形成聚合物-药物-PBRM结合物的聚合物支架，包括结合物的组合物，其制备方法以及使用结合物或其组合物治疗各种疾病的方法。
• Synthesis and composition of photodynamic therapeutic agents for the targeted treatment of cancer
  申请人：On Target Laboratories, LLC

  公开号：US10676487B2

  公开（公告）日：2020-06-09

  The present invention describes new compounds that are useful for image-guided surgery and photodynamic therapy. In particular the compounds may be targeted to the nucleus or the mitochondria after compounds were delivered to diseased tissues such as cancer using a ligand that target receptor that express on the diseased tissue and followed by receptor mediated endocytosis and provide effective activity against cancer cells as well as other disorders. Methods and compositions for use of the same are described.

  本发明描述了可用于图像引导手术和光动力疗法的新型化合物。 特别是，这些化合物可通过使用针对病变组织上表达的受体的配体，然后通过受体介导的内吞作用，将化合物递送至病变组织（如癌症）后靶向作用于细胞核或线粒体，并对癌细胞和其他疾病提供有效的活性。 本文还介绍了使用这些配体的方法和组合物。
• SYNTHESIS AND COMPOSITION OF PHOTODYNAMIC THERAPEUTIC AGENTS FOR THE TARGETED TREATMENT OF CANCER
  申请人：On Target Laboratories, LLC

  公开号：EP3347010A1

  公开（公告）日：2018-07-18
• US8821850B2
  申请人：——

  公开号：US8821850B2

  公开（公告）日：2014-09-02
• [EN] SYNTHESIS AND COMPOSITION OF PHOTODYNAMIC THERAPEUTIC AGENTS FOR THE TARGETED TREATMENT OF CANCER<br/>[FR] SYNTHÈSE ET COMPOSITION D'AGENTS THÉRAPEUTIQUES PHOTODYNAMIQUES POUR LE TRAITEMENT CIBLÉ DU CANCER
  申请人：ON TARGET LABORATORIES LLC

  公开号：WO2017044445A1

  公开（公告）日：2017-03-16

  The present invention describes new compounds that are useful for image-guided surgery and photodynamic therapy. In particular the compounds may be targeted to the nucleus or the mitochondria after compounds were delivered to diseased tissues such as cancer using a ligand that target receptor that express on the diseased tissue and followed by receptor mediated endocytosis and provide effective activity against cancer cells as well as other disorders. Methods and compositions for use of the same are described.