3-[[2-[(Z)-[1-[(4-fluorophenyl)methyl]-2,5-dioxoimidazolidin-4-ylidene]methyl]-6-methoxyphenoxy]methyl]benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-[[2-[(Z)-[1-[(4-fluorophenyl)methyl]-2,5-dioxoimidazolidin-4-ylidene]methyl]-6-methoxyphenoxy]methyl]benzoic acid
• 化学式: C₂₆H₂₁FN₂O₆
• 分子量: 476.5
• InChiKey: FIKLBAIUIBQTMZ-BKUYFWCQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Screening Method and Compounds for Modulating Telomerase Activity
  申请人：Skordalakes Emmanuel

  公开号：US20120309759A1

  公开（公告）日：2012-12-06

  The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain; or FP-pocket, PT-pocket or Th-pocket of telomerase and testing the compound for its ability to modulate the activity of telomerase. Compounds selected for interacting with the T-pocket or Fingers-Palm pocket of telomerase are also provided.
• SCREENING METHOD AND COMPOUNDS FOR MODULATING TELOMERASE ACTIVITY
  申请人：The Wistar Institute

  公开号：US20160067257A1

  公开（公告）日：2016-03-10

  The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain; or FP-pocket, PT-pocket or Th-pocket of telomerase and testing the compound for its ability to modulate the activity of telomerase. Compounds selected for interacting with the T-pocket or Fingers-Palm pocket of telomerase are also provided.
• US9234230B2
  申请人：——

  公开号：US9234230B2

  公开（公告）日：2016-01-12
• [EN] SCREENING METHOD AND COMPOUNDS FOR MODULATING TELOMERASE ACTIVITY<br/>[FR] PROCEDE DE CRIBLAGE ET COMPOSES POUR MODULER L'ACTIVITE DE LA TELOMERASE
  申请人：WISTAR INST

  公开号：WO2011097600A1

  公开（公告）日：2011-08-11

  The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, "thumb," "finger," and/or "palm" domain; or FP-pocket, PT-pocket or Th-pocket of telomerase and testing the compound for its ability to modulate the activity of telomerase. Compounds selected for interacting with the T-pocket or Fingers-Palm pocket of telomerase are also provided.