N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-(morpholin-4-ylmethyl)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-(morpholin-4-ylmethyl)benzamide
• 化学式: C₂₈H₄₀N₄O₄
• 分子量: 496.6
• InChiKey: GFMMSEFSYJJFFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  83.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Substituted Benzene Compounds
  申请人：Kuntz Kevin Wayne

  公开号：US20140142083A1

  公开（公告）日：2014-05-22

  The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

  本发明涉及取代苯化合物。本发明还涉及含有这些化合物的制药组合物以及通过将这些化合物和制药组合物用于需要治疗的受试者的方法来治疗癌症。本发明还涉及将这些化合物用于研究或其他非治疗目的的使用。
• SUBSTITUTED BENZENE COMPOUNDS
  申请人：Epizyme, Inc.

  公开号：EP2697198B1

  公开（公告）日：2016-06-08
• Compositions and Methods to Inhibit EZH2 for the Treatment of Cardiovascular Diseases
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US20160340674A1

  公开（公告）日：2016-11-24

  The present invention relates to compositions and methods for treatment and/or prevention of a cardiovascular disease. In one embodiment, the invention provides compositions and methods for decreasing one or more of the level, production, and activity of EZH2.
• US9376422B2
  申请人：——

  公开号：US9376422B2

  公开（公告）日：2016-06-28
• [EN] COMPOSITIONS AND METHODS TO INHIBIT EZH2 FOR THE TREATMENT OF CARDIOVASCULAR DISEASES<br/>[FR] COMPOSITIONS ET MÉTHODES D'INHIBITION DE EZH2 POUR TRAITER DES MALADIES CARDIOVASCULAIRES
  申请人：UNIV ROCHESTER

  公开号：WO2015120372A2

  公开（公告）日：2015-08-13

  The present invention relates to compositions and methods for treatment and/or prevention of a cardiovascular disease. In one embodiment, the invention provides compositions and methods for decreasing one or more of the level, production, and activity of EZH2.