(NE)-N-[3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-methyl-1,3,5-oxadiazinan-4-ylidene]nitramide;morpholine;5-(2-octylsulfinylpropyl)-1,3-benzodioxole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: (NE)-N-[3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-methyl-1,3,5-oxadiazinan-4-ylidene]nitramide;morpholine;5-(2-octylsulfinylpropyl)-1,3-benzodioxole
• 化学式: C30H47ClN6O7S2
• 分子量: 703.3
• InChiKey: NUERCMVPDNENNC-GRQPBFIBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.08
• 重原子数：
  46
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  191
• 氢给体数：
  1
• 氢受体数：
  12

文献信息

• PLATINUM COMPOUND HAVING AMINO OR ALKYLAMINO-CONTAINING SUCCINIC ACID DERIVATIVES AS LEAVING GROUP, PREPARTION METHOD THEREOF, AND USE THEREOF
  申请人：BEIJING FSWELCOME TECHNOLOGY DEVELOPMENT CO., LTD.

  公开号：US20140349985A1

  公开（公告）日：2014-11-27

  Disclosed are a category of platinum compounds having amino- or alkylamino-containing succinato derivatives as leaving group, or pharmaceutically acceptable salts thereof, preparation method thereof, and medicinal compositions containing the compounds. Also disclosed is a use of the compounds in treating cell proliferative diseases, especially cancers. The platinum compounds of the present invention have high water solubility and small toxic side effect.

  本发明揭示了一类铂化合物，其具有氨基或烷基氨基含有琥珀酸酯衍生物作为脱离基团，或其药用可接受的盐，以及其制备方法，以及含有这些化合物的药物组合物。本发明还揭示了这些化合物在治疗细胞增殖性疾病，特别是癌症方面的用途。本发明的铂化合物具有高水溶性和小毒副作用。
• PLATINUM COMPOUNDS FOR TREATING CELL PROLIFERATIVE DISEASES, PREPARATION METHOD AND USE THEREOF
  申请人：Chen Xiaoping

  公开号：US20140142079A1

  公开（公告）日：2014-05-22

  Disclosed are a class of platinum compounds with a leaving group of malonic acid derivatives containing amino and alkylamino, their pharmaceutically acceptable salts, their preparation methods and pharmaceutical composites comprising them. Disclosed also are for the uses of the compounds in the treatment of cell proliferative diseases, particularly for the treatment of cancers. The present platinum compounds have high water solubility and low toxicity.

  本文披露了一类铂化合物，其离去基为含有氨基和烷基氨基的丙二酸衍生物，以及它们的药用可接受盐、制备方法和包括它们的药用组合物。本文还披露了这些化合物在治疗细胞增殖性疾病，特别是治疗癌症方面的用途。这些铂化合物具有高水溶性和低毒性。
• PLATINUM COMPOUND OF MALONIC ACID DERIVATIVE HAVING LEAVING GROUP CONTAINING AMINO OR ALKYLAMINO
  申请人：BEIJING FSWELCOME TECHNOLOGY DEVELOPMENT, CO., LTD

  公开号：EP2924044A1

  公开（公告）日：2015-09-30

  Disclosed are a class of platinum compounds of malonic acid derivatives having a leaving group containing an amino or alkylamino, and pharmaceutically acceptable salt thereof, preparation method thereof and pharmaceutical composition containing the compounds. Also disclosed are uses of the compounds for treating cell proliferative diseases especially cancers. The platinum compounds of the present invention have high solubility in water, low toxicity and strong anti-tumor effect.

  本发明公开了一类具有含氨基或烷基氨基离去基团的丙二酸衍生物的铂化合物及其药学上可接受的盐、制备方法和含有该化合物的药物组合物。本发明还公开了这些化合物用于治疗细胞增殖性疾病，特别是癌症的用途。本发明的铂化合物在水中的溶解度高，毒性低，抗肿瘤作用强。
• PLATINUM COMPOUND HAVING AMINO- OR ALKYLAMINO-CONTAINING SUCCINIC ACID DERIVATIVES AS LEAVING GROUP, PREPARATION METHOD THEREFOR, AND USE THEREOF
  申请人：Beijing Fswelcome Technology Development Co., Ltd

  公开号：EP2759547B1

  公开（公告）日：2017-01-18
• PLATINUM COMPOUNDS FOR TREATING CELL PROLIFERATIVE DISEASE, PREPARATION METHODS AND USES THEREOF
  申请人：BEIJING FSWELCOME TECHNOLOGY DEVELOPMENT, CO., LTD

  公开号：EP2740738B1

  公开（公告）日：2018-03-28