(4-methoxyphenyl)methyl (6R,7R)-3-(chloromethyl)-4-methylidene-7-[[(2Z)-2-[2-methyl-1-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]oxyimino-2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]-1,3-thiazol-4-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (4-methoxyphenyl)methyl (6R,7R)-3-(chloromethyl)-4-methylidene-7-[[(2Z)-2-[2-methyl-1-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]oxyimino-2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]-1,3-thiazol-4-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• 化学式: C₃₅H₄₂ClN₅O₁₀S₂
• 分子量: 792.3
• InChiKey: JTYBXUZYPZSAMC-UHJHHEMYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  53
• 可旋转键数：
  17
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  238
• 氢给体数：
  2
• 氢受体数：
  14

文献信息

• PROCESSES FOR PRODUCTION OF INTERMEDIATES FOR 2-ALKYL CEPHEM COMPOUNDS
  申请人：SHIONOGI & CO., LTD.

  公开号：US20150291619A1

  公开（公告）日：2015-10-15

  The invention relates to processes for the production of intermediates for preparing 2-alkyl cephem compounds useful as antimicrobial drugs. The invention provides a process which comprises oxidating a compound of the formula (I) or a salt thereof to give a compound of the formula (II) or a salt thereof wherein each symbol is as defined in the specification.
• US9527866B2
  申请人：——

  公开号：US9527866B2

  公开（公告）日：2016-12-27
• [EN] PROCESSES FOR PRODUCTION OF INTERMEDIATES FOR 2-ALKYL CEPHEM COMPOUNDS<br/>[FR] PROCÉDÉS DE PRODUCTION D'INTERMÉDIAIRES DE COMPOSÉS DE TYPE 2-ALKYLCEPHEM
  申请人：SHIONOGI & CO

  公开号：WO2014069649A1

  公开（公告）日：2014-05-08

  The invention relates to processes for the production of intermediates for preparing 2-alkyl cephem compounds useful as antimicrobial drugs. The invention provides a process which comprises oxidating a compound of the formula (I) or a salt thereof to give a compound of the formula (II) or a salt thereof wherein each symbol is as defined in the specification.