3-(5-(trifluoromethyl)pyridin-2-yl)pyrazolo[1,5-a]pyridine-5-carboxylic acid | 1610612-08-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(5-(trifluoromethyl)pyridin-2-yl)pyrazolo[1,5-a]pyridine-5-carboxylic acid
• 英文别名: 3-[5-(Trifluoromethyl)pyridin-2-yl]pyrazolo[1,5-a]pyridine-5-carboxylic acid；3-[5-(trifluoromethyl)pyridin-2-yl]pyrazolo[1,5-a]pyridine-5-carboxylic acid
• CAS: 1610612-08-2
• 化学式: C₁₄H₈F₃N₃O₂
• 分子量: 307.232
• InChiKey: ACYWUHZHDOUWOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  67.5
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR LE TRAITEMENT DE MALADIES PARASITAIRES
  申请人：IRM LLC

  公开号：WO2014078802A1

  公开（公告）日：2014-05-22

  The present invention provides compounds of formula I: [INSERT FORMULA HERE] or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

  本发明提供了化合物的公式I：[在此插入公式]或其药学上可接受的盐、互变异构体或立体异构体，其中变量如本文所定义。本发明还提供了包含这种化合物的药物组合物以及使用这种化合物用于治疗、预防、抑制、改善或根除由疟原虫引起的疾病的病理学和/或症状学的方法，例如疟疾。
• COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES
  申请人：Chatterjee Arnab Kumar

  公开号：US20140155367A1

  公开（公告）日：2014-06-05

  The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

  本发明提供了式I的化合物：或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。本发明还提供了包含这种化合物的制药组合物以及使用这种化合物治疗、预防、抑制、改善或根除由疟原虫（如疟疾）引起的病理和/或症状的方法。
• NON-AQUEOUS ELECTROLYTE AND ELECTRICITY STORAGE DEVICE USING SAME
  申请人：UBE Industries, Ltd.

  公开号：EP2744030A1

  公开（公告）日：2014-06-18

  The present invention provides a nonaqueous electrolytic solution capable of improving electrochemical characteristics in a broad temperature range, such as low-temperature cycle properties and low-temperature discharge properties after high-temperature storage, and provides an energy storage device using the nonaqueous electrolytic solution. The invention includes (1) a nonaqueous electrolytic solution of an electrolyte salt dissolved in a nonaqueous solvent, which comprises from 0.001 to 10% by mass of a compound represented by the following general formula (I), and (2) an energy storage device comprising a positive electrode, a negative electrode, and a nonaqueous electrolytic solution of an electrolyte salt dissolved in a nonaqueous solvent, wherein the nonaqueous electrolytic solution is the nonaqueous electrolytic solution of (1). (In the formula, Y represents a group -C(=O)- or a group -S(=O)2-; R3 and R4 each independently represent an aryl group having from 6 to 10 carbon atoms in which at least one hydrogen atom is substituted with a halogen atom, or R3 and R4 bonding to each other represent a cycloalkanediyl group or a benzenediyl group, having from 5 to 12 carbon atoms. R represents -C(R1)(R2)- or -L-; R1 and R2 each independently represent a hydrogen atom, a halogen atom, or an alkyl group having from 1 to 4 carbon atoms; and L represents a divalent linking group having from 1 to 6 carbon atoms and optionally substituted with a halogen atom.)

  本发明提供了一种非水性电解溶液，能够改善在宽温度范围内的电化学特性，例如低温循环特性和高温储存后的低温放电特性，并提供了一种使用该非水性电解溶液的储能装置。本发明包括：（1）溶解在非水溶剂中的电解质盐的非水性电解溶液，该溶液包含 0.001 至 10%（按质量计）由以下通式（I）表示的化合物；（2）一种储能装置，该装置包括正极、负极和溶解在非水溶剂中的电解质盐的非水性电解溶液，其中非水性电解溶液是（1）的非水性电解溶液。 (式中，Y 代表-C(＝O)-基团或-S(＝O)2-基团；R3 和 R4 各自独立地代表具有 6 至 10 个碳原子的芳基，其中至少一个氢原子被卤原子取代，或 R3 和 R4 相互结合代表具有 5 至 12 个碳原子的环烷二基或苯二基。R 代表-C(R1)(R2)-或-L-；R1 和 R2 各自独立地代表氢原子、卤素原子或具有 1 至 4 个碳原子的烷基；L 代表具有 1 至 6 个碳原子并可选地被卤素原子取代的二价连接基团)。
• US8871754B2
  申请人：——

  公开号：US8871754B2

  公开（公告）日：2014-10-28
• US9236635B2
  申请人：——

  公开号：US9236635B2

  公开（公告）日：2016-01-12