[3-(Hydroxymethyl)phenyl]methyl formate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [3-(Hydroxymethyl)phenyl]methyl formate
• 英文别名: [3-(hydroxymethyl)phenyl]methyl formate
• 化学式: C₉H₁₀O₃
• 分子量: 166.17
• InChiKey: DNNHKPZZFCPKGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Method for peptide synthesis
  申请人：Lalezari Iraj

  公开号：US20140142279A1

  公开（公告）日：2014-05-22

  A new method based on the synthesis and use of novel N and C protecting agents. The new N-protecting agent, here referred to as V-Phenol, generates V-protected amino acids and can be successfully applied to all conventional peptide bond formations including active esters, N,N′-dicyclohexylcarbodiimide (DCC) or related dehydrating agents mixed anhydride methods, PC13 and related agents. The new C-protecting agent, here referred to as HONE, can be successfully applied to peptide synthesis as an active ester not only in combination with V-protected amino acids but also with other N-protecting agents such as Cbz, Boc, Fmoc, etc.

  一种基于新型N和C保护试剂的合成和使用的新方法。新的N保护试剂，此处称为V-苯酚，生成V保护的氨基酸，可成功应用于所有传统的肽键形成，包括活性酯，N，N′-二环己基碳二亚胺（DCC）或相关的脱水试剂混合酰方法，PC13和相关试剂。新的C保护试剂，此处称为HONE，在肽合成中可以成功地作为活性酯应用，不仅与V保护的氨基酸相结合，还可以与其他N保护试剂如Cbz、Boc、Fmoc等相结合。
• Antimicrobial and antifouling catechol-containing polycarbonates for medical applications
  申请人：International Business Machines Corporation

  公开号：US10183099B2

  公开（公告）日：2019-01-22

  Catechol-bearing polycarbonates (catechol polymers) were prepared comprising i) a catechol repeat unit comprising a side chain catechol group, ii) a cationic repeat unit comprising a side chain cationic group selected from the group consisting of quaternary amine groups, quaternary phosphine groups, and combinations thereof, and iii) a PEG repeat unit comprising a side chain poly(ethylene oxide) group having a degree of polymerization of about 5 to about 30. The catechol polymers form antimicrobial and antifouling films on a variety of substrate surfaces, in particular silicone rubber.

  所制备的含邻苯二酚的聚碳酸酯（邻苯二酚聚合物）包含 i) 由侧链邻苯二酚基团组成的邻苯二酚重复单元；ii) 由侧链阳离子基团组成的阳离子重复单元，该侧链阳离子基团选自季胺基团、季膦基团及其组合；以及 iii) 由侧链聚环氧乙烷基团组成的 PEG 重复单元，其聚合度约为 5 至 30。邻苯二酚聚合物可在各种基材表面，特别是硅橡胶表面形成抗菌防污膜。
• Antimicrobial cationic polycarbonates
  申请人：International Business Machines Corporation

  公开号：US10786530B2

  公开（公告）日：2020-09-29

  Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.

  通过有机催化开环聚合法制备了具有一条或两条阳离子聚碳酸酯链的抗菌阳离子聚合物。一种抗菌阳离子聚合物的聚合物链主要由与一个或两个端基相连的阳离子碳酸酯重复单元组成。端基可包括共价结合形式的生物活性化合物，如胆固醇。其他抗菌阳离子聚合物具有无规共聚碳酸酯链，该链由一小部分疏水重复单元组成，其中含有共价结合形式的维生素 E 和/或维生素 D2。这些阳离子聚合物对革兰氏阴性和革兰氏阳性微生物和真菌具有很高的活性和选择性。
• VITAMIN FUNCTIONALIZED GEL-FORMING BLOCK COPOLYMERS FOR BIOMEDICAL APPLICATIONS
  申请人：International Business Machines Corporation

  公开号：US20170051105A1

  公开（公告）日：2017-02-23

  Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.
• US9631050B2
  申请人：——

  公开号：US9631050B2

  公开（公告）日：2017-04-25