4-[(2,4-dichlorophenoxy)methyl]-N-[2-(dimethylamino)ethyl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[(2,4-dichlorophenoxy)methyl]-N-[2-(dimethylamino)ethyl]benzamide
• 化学式: C₁₈H₂₀Cl₂N₂O₂
• 分子量: 367.3
• InChiKey: YLBHFMUBTMFLKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] NEW ANTIFUNGAL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS ANTIFONGIQUES
  申请人：URBAN CONSTANTIN

  公开号：WO2019216810A1

  公开（公告）日：2019-11-14

  Compounds of the formulae wherein the bond α is a single bond, a trans double bond (E), or a triple bond; X and Y are -CH2- or on of X and Y is O and the other is CH2; R1 is phenyl unsubstituted or substituted with one, two, or three substituents each independently selected from chloro, bromo, trifluoromethyl; R2 is or –NH-(CH2)n-R3 where n is 2 or 3, the other variables are as provided herein, pharmaceutical compositions comprising these compounds and their use in the treatment, prophylaxis or prevention of fungal infections, especially candida infections, and related aspects are provided.