1-Tert-butylsulfonyl-2-nitro-4-(trifluoromethyl)benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Tert-butylsulfonyl-2-nitro-4-(trifluoromethyl)benzene
• 英文别名: 1-tert-butylsulfonyl-2-nitro-4-(trifluoromethyl)benzene
• 化学式: C11H12F3NO4S
• 分子量: 311.28
• InChiKey: DNINBXQSQGGTRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  88.3
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• METHOD FOR SCREENING ANTI-CANCER DRUGS AND METHOD OF CANCER TREATMENT
  申请人：National Taiwan University

  公开号：US20140148482A1

  公开（公告）日：2014-05-29

  The present application provides a method for screening compounds for cancer treatment comprising treating cancer cells with a candidate compound for sufficient time for detectable expression of a gene selected from GADD45 family; and detecting the level of expression of the gene as compared to the level of expression in the absence of the candidate compound; wherein an increased level of expression in the presence of the candidate compound as compared to expression in the absence of the candidate compound indicates that the candidate compound acts as an inhibitor of the cancer cells. In some embodiments, the method can be used for screening compounds for treatment of sorafenib-resistant hepatocellular carcinoma. The present application further provides a method for treating hepatocellular carcinoma comprising administering to a subject having hepatocellular carcinoma a therapeutic effective amount of an agonist of GADD45 family.
• AGONISTS OF SRC HOMOLOGY-2 CONTAINING PROTEIN TYROSINE PHOSPHATASE-1 AND TREATMENT METHODS USING THE SAME
  申请人：Shiau Chung-Wai

  公开号：US20140200239A1

  公开（公告）日：2014-07-17

  The present invention provides new compounds of formula I, II or III, which have Src homology-2 containing protein tyrosine phosphatase-1 (SHP-1) agonist activity. Also provided are treatment methods using the compounds of formula I, II or III.
• LUCIFERIN DERIVATIVES FROM BICYCLIC REACTANTS AND AMINOTHIOL DERIVATIVES AND METHODS OF USE THEREOF
  申请人：The Regents of the University of California

  公开号：US20190290784A1

  公开（公告）日：2019-09-26

  The present disclosure features a condensation reaction and a luciferin-unmasking reaction that can be carried out under physiological conditions. In general, the condensation reaction involves reacting a bicyclic reactant with an aminothiol derivative, generating a luciferin or luciferin derivative. A luciferin can provide detectable luminescence. A luciferin derivative can be unmasked to provide detectable luminescence in a luciferin-unmasking reaction. The present disclosure provides bicyclic reactants and aminothiol derivatives suitable for use in the condensation reaction. The condensation and luciferin-unmasking reactions find use in a variety of applications, which are also provided.
• US9090617B1
  申请人：——

  公开号：US9090617B1

  公开（公告）日：2015-07-28
• US9216950B2
  申请人：——

  公开号：US9216950B2

  公开（公告）日：2015-12-22