6-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyridin-3-amine | 1612287-45-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyridin-3-amine
• 英文别名: NUCC-0200688；6-[2-Methyl-5-(trifluoromethyl)pyrazol-3-yl]pyridin-3-amine；6-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]pyridin-3-amine
• CAS: 1612287-45-2
• 化学式: C₁₀H₉F₃N₄
• 分子量: 242.203
• InChiKey: WJFMGSFKLPLCGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  56.7
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• New bicyclic compounds as crac channel modulators
  申请人：Almirall, S.A.

  公开号：EP2738172A1

  公开（公告）日：2014-06-04

  The present invention relates to novel compounds which are inhibitors of CRAC channel activity. This invention also relates to pharmaceutical compositions containing them, process for their preparation and their use in therapy.

  这项发明涉及一种新型化合物，它们是CRAC通道活性的抑制剂。该发明还涉及含有这些化合物的药物组合物，它们的制备方法以及它们在治疗中的应用。
• SUBSTITUTED HETEROCYCLES AS c-MYC TARGETING AGENTS
  申请人：NORTHWESTERN UNIVERSITY

  公开号：US20200392116A1

  公开（公告）日：2020-12-17

  Disclosed are substituted heterocycle compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.

  本文披露了包括取代吡唑、取代嘧啶和取代三唑在内的取代杂环化合物。本文披露的取代杂环化合物被证明在抑制c-MYC方面具有用途，并可用作治疗癌症和细胞增殖性疾病的治疗药物。
• [EN] SUBSTITUTED HETEROCYCLES AS C-MYC TARGETING AGENTS<br/>[FR] HÉTÉROCYCLES SUBSTITUÉS SERVANT D'AGENTS DE CIBLAGE DE C-MYC
  申请人：UNIV NORTHWESTERN

  公开号：WO2020046382A1

  公开（公告）日：2020-03-05

  Disclosed are substituted heterocycle compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.

  本文披露了包括取代吡唑、取代嘧啶和取代三唑在内的取代杂环化合物。本文披露的取代杂环化合物已被证明在抑制c-MYC方面具有用途，并可用作治疗癌症和细胞增殖性疾病的治疗药物。
• Substituted heterocycles as c-MYC targeting agents
  申请人：Northwestern University

  公开号：US11142504B2

  公开（公告）日：2021-10-12

  Disclosed are substituted heterocycle compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.

  公开的取代杂环化合物包括取代吡唑、取代嘧啶和取代三唑。本文所公开的取代杂环化合物具有抑制 c-MYC 的作用，可用作治疗癌症和细胞增殖性疾病的药物。
• SPECIFIC 2-(4-(PHENOXY)-1H-PYRAZOL-3-YL)PHENOL DERIVATIVES AS INHIBITORS OF C-MYC/DNA BINDING ACTIVITY FOR TREATING CANCER
  申请人：Northwestern University

  公开号：EP3426636B1

  公开（公告）日：2021-12-29