2-(N-(5-Chloro-2-methylphenyl)methylsulfonamido)-N-(2,6-difluorophenyl)acetamide | 708219-39-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(N-(5-Chloro-2-methylphenyl)methylsulfonamido)-N-(2,6-difluorophenyl)acetamide
• 英文别名: 2-(5-chloro-2-methyl-N-methylsulfonylanilino)-N-(2,6-difluorophenyl)acetamide
• CAS: 708219-39-0
• 化学式: C₁₆H₁₅ClF₂N₂O₃S
• 分子量: 388.8
• InChiKey: WAOBCCBUTHNTFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF
  申请人：THE BROAD INSTITUTE, INC.

  公开号：US20160031837A1

  公开（公告）日：2016-02-04

  The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention. Liver disease affects more than 500 million people worldwide. Organ transplantation is the gold standard for treatment of liver failure, but organ shortages are acute.

  本发明提供了诱导细胞增殖和/或分化的方法，包括将细胞与本发明方法中的化合物接触。本发明还提供了通过本发明方法获得的细胞。肝病影响全球超过5亿人。器官移植是治疗肝衰竭的金标准，但器官短缺严重。
• HIGHLY FUNCTIONAL LIVER CELLS, AND USE THEREOF
  申请人：Yonemitsu, Yoshikazu

  公开号：EP3431586A1

  公开（公告）日：2019-01-23

  The object is to obtain a highly functional hepatocyte that has a high ammonia-metabolizing function and is theoretically able to infinitely proliferate from a human iPS cell. There is provided a method for preparing an artificial hepatocyte comprising the following steps: the differentiation induction step 1 of culturing an iPS cell in a differentiation induction medium I containing activin A; the differentiation induction step 2 of culturing a cell obtained in the differentiation induction step 1 in a differentiation induction medium II containing bone morphogenetic protein 4 (BMP4) and fibroblast growth factor 2 (FGF2); and the differentiation induction step 3 of culturing a cell obtained in the differentiation induction step 2 in a differentiation induction medium III containing hepatocyte growth factor (HGF), oncostatin M, dexamethasone, and N,N'-(methylenebis)(4,1-phenylene)diacetamide (FH1) and/or 2-([N-(5-chloro-2-methylphenyl)(methylsulfonamido)-N-(2,6-difluorophenyl)acetamide (FPH1) to obtain an artificial hepatocyte. The obtained artificial hepatocyte has an ammonia-metabolizing function of 100 µg/dl/24h or higher, and can constitute a mesh structure.

  目的是获得一种高功能肝细胞，该肝细胞具有高氨代谢功能，理论上能够从人类 iPS 细胞无限增殖。本发明提供了一种制备人工肝细胞的方法，包括以下步骤：分化诱导步骤 1：在含有活化素 A 的分化诱导培养基 I 中培养 iPS 细胞； 分化诱导步骤 2：在含有骨形态发生蛋白 4（BMP4）和成纤维细胞生长因子 2（FGF2）的分化诱导培养基 II 中培养在分化诱导步骤 1 中获得的细胞；分化诱导步骤 3：在分化诱导培养基 III 中培养分化诱导步骤 2 中获得的细胞，该培养基 III 含有肝细胞生长因子（HGF）、昂科司他丁 M、N,N'-(亚甲基双)(4,1-亚苯基)二乙酰胺(FH1)和/或 2-([N-(5-氯-2-甲基苯基)(甲磺酰胺基)-N-(2,6-二氟苯基)乙酰胺(FPH1))，以获得人造肝细胞。获得的人工肝细胞的氨代谢功能为 100 µg/dl/24h 或更高，并可构成网状结构。
• EXTRACORPOREAL ARTIFICIAL LIVER AND DEVICE FOR EXTRACORPOREAL ARTIFICIAL LIVER OR CULTURE OF HEPATOCYTES
  申请人：Yonemitsu Yoshikazu

  公开号：US20200061276A1

  公开（公告）日：2020-02-27

  An object of the present invention is to provide an artificial liver using highly functional hepatocytes. There is provided an extracorporeal artificial liver having at least one module comprising the followings: a plasma ingredient inlet port, and a plasma ingredient outlet port; a plasma ingredient circulation chamber having the plasma ingredient inlet port, and the plasma ingredient outlet port; and a hepatocyte culture chamber provided adjacently to the plasma ingredient circulation chamber and separated from the plasma ingredient circulation chamber with a separation membrane through which ammonia can permeate, but hepatocytes cannot permeate, in which hepatocytes having an ammonia-metabolizing ability are cultured.
• [EN] COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS D'INDUCTION DE LA PROLIFÉRATION ET DE LA DIFFÉRENCIATION DE CELLULES ET PROCÉDÉS D'UTILISATION CORRESPONDANTS
  申请人：BROAD INST INC

  公开号：WO2014144125A1

  公开（公告）日：2014-09-18

  The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention. Liver disease affects more than 500 million people worldwide. Organ transplantation is the gold standard for treatment of liver failure, but organ shortages are acute.