[4-(chloromethyl)-1H-pyrazol-5-yl]-[4-[2-(3-fluorophenyl)ethyl]piperazin-1-yl]methanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [4-(chloromethyl)-1H-pyrazol-5-yl]-[4-[2-(3-fluorophenyl)ethyl]piperazin-1-yl]methanone
• 化学式: C₁₇H₂₀ClFN₄O
• 分子量: 350.8
• InChiKey: HSRYYJAYGHQXEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  52.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
  申请人：Arena Pharmaceuticals, Inc.

  公开号：EP2066641B1

  公开（公告）日：2014-06-04
• [EN] USE OF 5HT2A INVERSE AGONISTS FOR TREATING PSYCHOSIS<br/>[FR] UTILISATION D'AGONISTES INVERSES DE 5 HT2A POUR LE TRAITEMENT DE PSYCHOSES
  申请人：AXOVANT SCIENCES GMBH

  公开号：WO2019033068A1

  公开（公告）日：2019-02-14

  Disclosed herein are methods of using a 5-HT2A serotonin receptor inverse agonist for the prophylaxis and/or treatment of psychosis or psychotic symptoms in an individual comprising administering to said individual in need thereof a therapeutically effective amount of said 5-HT2A serotonin receptor inverse agonist. Further disclosed herein are methods of using a 5-HT2A serotonin receptor inverse agonist for the prophylaxis and/or treatment of Parkinson's disease psychosis in an individual comprising administering to said individual in need thereof a therapecutically effective amount of said 5-HT2A serotonin receptor inverse agonist.