2,8a-Dihydronaphthalene-1,8-dithione

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代羰基化合物
• 英文名称: 2,8a-Dihydronaphthalene-1,8-dithione
• 英文别名: 2,8a-dihydronaphthalene-1,8-dithione
• 化学式: C₁₀H₈S₂
• 分子量: 192.3
• InChiKey: JBPOBUNVSWQIBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  64.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• NOVEL SYNTHETIC ANTIOXIDANTS AND THEIR USES
  申请人：Lu, Yansong

  公开号：EP2925719A1

  公开（公告）日：2015-10-07
• US9994519B2
  申请人：——

  公开号：US9994519B2

  公开（公告）日：2018-06-12
• [EN] NOVEL SYNTHETIC ANTIOXIDANTS AND THEIR USES<br/>[FR] NOUVEAUX ANTIOXYDANTS DE SYNTHÈSE ET LEURS UTILISATIONS
  申请人：LU YANSONG

  公开号：WO2014084898A1

  公开（公告）日：2014-06-05

  The present invention relates to synthetic organic antioxidants of small molecules. The novel dithiol-containing compounds in this invention possess strongest possible capability as both scavenger for free radicals and antioxidant. This invention is directed to novel molecules as prodrugs of the novel dithiol-containing compounds, their rational design, their feasible preparation route by means of synthetic organic chemistry, and their potential uses in application to treatment and/or prevention of major diseases associated with oxidative stress, such as Alzheimer's disease, Parkinson's disease, cancer, diabetes, HIV, acne, cardiovascular disease, renal disease, hypertension, hypercholesterolemia, hyperlipidemia, rheumatoid arthritis, inflammation, pain, aging, stroke, cataract, glaucoma, age-related macular degeneration, etc.
• [EN] NOVEL SYNTHETIC ASPIRIN-MIMICS AND INNOVATIVE ANTIOXIDANTS AND THEIR USES<br/>[FR] NOUVEAUX ANALOGUES DE SYNTHÈSE DE L'ASPIRINE ET ANTIOXYDANTS NOVATEURS ET LEURS UTILISATIONS
  申请人：LU YANSONG

  公开号：WO2015053797A2

  公开（公告）日：2015-04-16

  The present invention relates to novel synthetic aspirin-mimics that mimic the molecular structure of aspirin, with sulfur to replace oxygen in the key functional groups of aspirin. The novel synthetic aspirin-mimics in this invention integrate multiple features/functions: 1. they are considered as "druggable", as they resemble aspirin in structure; 2. they possess the strongest possible capability as scavengers for free radicals; 3. they could reinstate some damaged proteins/enzymes via the mechanism of thiol-disulfide exchange; 4. they are better chelators to heavy metals and could efficiently remove heavy metals out of body, compared to aspirin. This invention is also directed to novel aspirin-mimics as both drugs and prodrugs, their rational design, their feasible preparation routes by means of synthetic organic chemistry, and their potential therapeutic uses including but not limited to, in treatment and/or prevention of major diseases associated with oxidative stress, such as Alzheimer's disease, Parkinson's disease, cancers, diabetes, cardiovascular disease, renal disease, HIV, pain, hypertension, hypercholesterolemia, hyperlipidemia, rheumatoid arthritis, inflammation, aging, stroke, cataract, glaucoma, age-related macular degeneration, depression, acne, etc.