[2-(Aminomethyl)phenyl] cyclopropanecarboxylate;hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: [2-(Aminomethyl)phenyl] cyclopropanecarboxylate;hydrochloride
• 英文别名: [2-(aminomethyl)phenyl] cyclopropanecarboxylate;hydrochloride
• 化学式: C11H14ClNO2
• 分子量: 227.69
• InChiKey: UUGFQUBKFDAHOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.88
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  52.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• COMPOSITIONS AND METHODS FOR TREATING CANCER
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2925888A1

  公开（公告）日：2015-10-07
• [EN] COMPOSITIONS AND METHODS FOR TREATING CANCER<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR TRAITER LE CANCER
  申请人：MERCK SHARP & DOHME

  公开号：WO2014085216A1

  公开（公告）日：2014-06-05

  The instant invention relates to methods for the treatment of WEE1 kinase associated cancer by administering a WEE1 inhibitor, wherein the WEE1 inhibitor is WEE1-1 or a pharmaceutically acceptable salt thereof, or WEE1-2 or a pharmaceutically acceptable salt thereof. In another embodiment, the invention relates to a method for treating a WEE1 kinase associated cancer patient, comprising administering a WEE1 inhibitor, wherein the cancer cells of said patient to be treated are characterized by low expression levels of PKMYT1.