4-[(E)-2-[4-(2-hydroxyethylamino)phenyl]ethenyl]-5,5-dimethyl-2-oxofuran-3-carbonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[(E)-2-[4-(2-hydroxyethylamino)phenyl]ethenyl]-5,5-dimethyl-2-oxofuran-3-carbonitrile
• 化学式: C₁₇H₁₈N₂O₃
• 分子量: 298.34
• InChiKey: MWMXRHRCNGTRGT-VMPITWQZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  82.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• METHODS OF DETECTING MYELIN BASIC PROTEIN
  申请人：GENERAL ELECTRIC COMPANY

  公开号：US20140154178A1

  公开（公告）日：2014-06-05

  A method and a kit for detecting myelin basic protein are provided. The method comprises administering an agent, which binds to myelin basic protein (MBP), to a subject at risk of or diagnosed with a myelin-associated neuropathy, and determining myelination by detecting the agent resided in the subject. The amount of the agent present in the subject is indicative of a myelin-associated neuropathy. A method of quantifying an amount of MBP present in a tissue sample is also provided, wherein the method comprises contacting the tissue sample with the same agent, detecting the agent present in the tissue sample; and quantifying an amount of the agent present in the tissue sample.

  提供了一种检测髓鞘碱性蛋白的方法和试剂盒。该方法包括向患有或有风险患上髓鞘相关神经病的受试者施用结合到髓鞘碱性蛋白（MBP）的试剂，并通过检测附着在受试者身上的试剂来确定髓鞘形成情况。受试者中试剂的存在量表明了髓鞘相关神经病的存在。还提供了一种量化组织样本中MBP存在量的方法，其中该方法包括将组织样本与相同的试剂接触，检测组织样本中存在的试剂，并量化组织样本中存在的试剂的数量。
• US9040019B2
  申请人：——

  公开号：US9040019B2

  公开（公告）日：2015-05-26