N,2-dichloro-5-methoxyaniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,2-dichloro-5-methoxyaniline
• 化学式: C₇H₇Cl₂NO
• 分子量: 192.04
• InChiKey: HAXPGFQETXIUKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] ZINC HALIDE MEDIATED CYCLIZATION PROCESS LEADING TO TRICYCLIC INDOLES<br/>[FR] PROCÉDÉ DE CYCLISATION PAR HALOGÉNURE DE ZINC PERMETTANT L'OBTENTION D'INDOLES TRICYCLIQUES
  申请人：GE HEALTHCARE LTD

  公开号：WO2014083163A1

  公开（公告）日：2014-06-05

  The present invention relates to a method for the production of tricyclic indole compounds comprising a cyclization step wherein this step is improved over known methods.

  本发明涉及一种用于生产三环吲哚化合物的方法，包括一个环化步骤，其中这一步骤在已知方法的基础上得到改进。
• Dry Powder Drug Delivery System and Methods
  申请人：Smutney Chad C.

  公开号：US20130104887A1

  公开（公告）日：2013-05-02

  A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, endocrine disease such as diabetes and/or obesity.
• CRYSTALLIZATION PROCESS OF TRICYCLIC INDOLE DERIVATIVES
  申请人：GE Healthcare Limited

  公开号：US20150335766A1

  公开（公告）日：2015-11-26

  A composition comprising a tricyclic indole compound. The composition has a higher purity and better impurity profile than known compositions comprising said tricyclic indole compound and as a consequence has superior properties, particularly when said compound is destined for use in vivo as a therapeutic or diagnostic agent.
• Zinc Halide Mediated Cyclization Process Leading to Tricyclic Indoles
  申请人：GE Healthcare Limited

  公开号：US20150336891A1

  公开（公告）日：2015-11-26

  The present invention relates to a method for the production of tricyclic indole compounds comprising a cyclization step wherein this step is improved over known methods.
• US9475769B2
  申请人：——

  公开号：US9475769B2

  公开（公告）日：2016-10-25