1-(2-Methyl-4-nitrophenyl)-3-phenylurea | 13142-71-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-Methyl-4-nitrophenyl)-3-phenylurea
• CAS: 13142-71-7
• 化学式: C14H13N3O3
• 分子量: 271.27
• InChiKey: USFXVROWTKFBFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  87
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Carboxylesterase inhibitors
  申请人：Potter M. Philip

  公开号：US20050054691A1

  公开（公告）日：2005-03-10

  This disclosure relates to amides, aryl sulphonamides, aryl ureas, and α,β-diketones derivatives useful as carboxylesterase esterase inhibitors. The disclosure is also directed to the use of these compounds as selective human intestinal carboxylesterase inhibitors and insect carboxylesterase inhibitors. The disclosure is also directed to pharmaceutical compositions and pesticide formulations containing these compounds, and to methods for treating or ameliorating the toxic effects following administration of drugs such as cancer therapy drugs, treating or ameliorating the effects of a drug overdose, and to the use of the compounds for increasing the effectiveness of insecticides and pesticides.

  本公开涉及可用作羧酸酯酶抑制剂的酰胺类、芳基磺酰胺类、芳基脲类和 α,β-二酮衍生物。本发明还涉及这些化合物作为选择性人体肠道羧酯酶抑制剂和昆虫羧酯酶抑制剂的用途。本发明还涉及含有这些化合物的药物组合物和杀虫剂制剂，以及治疗或改善给药后的毒性效应（如癌症治疗药物）、治疗或改善药物过量效应的方法，以及使用这些化合物提高杀虫剂和杀虫剂效力的方法。
• AMIDE, ARYL SULFONAMIDE, ARYL UREA, AND a,b-DIKETONE DERIVED CARBOXYLESTERASE INHIBITORS, AND THEIR METHODS OF USE
  申请人：Potter Philip M.

  公开号：US20080146548A1

  公开（公告）日：2008-06-19

  This disclosure relates to amides, aryl sulphonamides, aryl ureas, and α,β-diketones derivatives useful as carboxylesterase esterase inhibitors. The disclosure is also directed to the use of these compounds as selective human intestinal carboxylesterase inhibitors and insect carboxylesterase inhibitors. The disclosure is also directed to pharmaceutical compositions and pesticide formulations containing these compounds, and to methods for treating or ameliorating the toxic effects following administration of drugs such as cancer therapy drugs, treating or ameliorating the effects of a drug overdose, and to the use of the compounds for increasing the effectiveness of insecticides and pesticides.
• [EN] CARBOXYLESTERASE INHIBITORS<br/>[FR] INHIBITEURS DE LA CARBOXYLESTERASE
  申请人：ST JUDE CHILDRENS RES HOSPITAL

  公开号：WO2005021721A2

  公开（公告）日：2005-03-10

  This disclosure relates to amides, aryl sulphonamides, aryl ureas, and (x,pdiketones derivatives useful as carboxylesterase esterase inhibitors. The disclosure is also directed to the use of these compounds as selective human intestinal carboxylesterase inhibitors and insect carboxylesterase inhibitors. The disclosure is also directed to pharmaceutical compositions and pesticide formulations containing these compounds, and to methods for treating or ameliorating the toxic effects following administration of drugs such as cancer therapy drugs, treating or ameliorating the effects of a drug overdose, and to the use of the compounds for increasing the effectiveness of insecticides and pesticides.