4-amino-6-(2,6-dichlorophenyl)-2-[5-[2-(diethylamino)ethylamino]-1-methyl-2-(oxomethylidene)-3H-pyrrol-3-yl]-8-methoxypyrido[2,3-d]pyrimidin-7-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-amino-6-(2,6-dichlorophenyl)-2-[5-[2-(diethylamino)ethylamino]-1-methyl-2-(oxomethylidene)-3H-pyrrol-3-yl]-8-methoxypyrido[2,3-d]pyrimidin-7-one
• 化学式: C₂₆H₂₉Cl₂N₇O₃
• 分子量: 558.5
• InChiKey: JGOFOOQWGXIHQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Pyrido-[2,3-D] Pyrimidines and Their Use as Kinase Inhibitors
  申请人：MURTHI KRISHNA

  公开号：US20140163003A1

  公开（公告）日：2014-06-12

  The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.