2-[2-hydroxy-1-(7H-purin-6-ylamino)ethyl]-3-phenylpyrrolo[1,2-a][1,3,5]triazin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-[2-hydroxy-1-(7H-purin-6-ylamino)ethyl]-3-phenylpyrrolo[1,2-a][1,3,5]triazin-4-one
• 化学式: C₁₉H₁₆N₈O₂
• 分子量: 388.4
• InChiKey: LJTAEJYPCUTFLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• PYRROLOTRIAZINONE DERIVATIVES AS P13K INHIBITORS
  申请人：Bernal Anchuela Francisco Javier

  公开号：US20140163033A1

  公开（公告）日：2014-06-12

  New pyrrolotriazinone derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks).

  本发明公开了具有化学结构公式（I）的新吡咯三唑酮衍生物；以及它们的制备过程，包括它们的药物组合物和它们作为磷脂酰肌醇3-激酶（PI3Ks）抑制剂在治疗中的使用。
• PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS
  申请人：Bernal Anchuela Francisco Javier

  公开号：US20150099752A9

  公开（公告）日：2015-04-09

  New pyrrolotriazinone derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks).

  本发明涉及一种具有化学结构式（I）的新型吡咯三唑酮衍生物，以及其制备方法、包含它们的制药组合物和它们作为磷脂酰肌醇3-激酶（PI3Ks）抑制剂在治疗中的应用。
• COMBINATION
  申请人：Almirall, S.A.

  公开号：US20170151264A1

  公开（公告）日：2017-06-01

  The present invention provides a pharmaceutical composition which comprises (a) a compound which is an inhibitor of phosphoinositide 3-kinase delta or a pharmaceutically acceptable salt and/or solvate thereof, and (b) a corticosteroid.
• MEDICAL USE
  申请人：Almirall, S.A.

  公开号：US20170189409A1

  公开（公告）日：2017-07-06

  The present invention provides a compound, which is an inhibitor of phosphoinositide 3-kinase delta or a pharmaceutically acceptable salt and/or solvate thereof, for use in the treatment of an immunobullous skin disease mediated by autoantibodies by oral administration.
• US9340547B2
  申请人：——

  公开号：US9340547B2

  公开（公告）日：2016-05-17