(2,2-dimethyl-1-spiro[2H-1-benzofuran-3,4'-piperidine]-5-ylpropyl) carbamate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: (2,2-dimethyl-1-spiro[2H-1-benzofuran-3,4'-piperidine]-5-ylpropyl) carbamate
• 化学式: C₁₈H₂₆N₂O₃
• 分子量: 318.4
• InChiKey: BFKZXZTVAFUKSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  73.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME
  申请人：Barany Francis

  公开号：US20140163229A1

  公开（公告）日：2014-06-12

  Described herein are silyl monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. Such multimer forming associations of monomers may be promoted by the proximal binding of the monomers to their target biomolecule(s). In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.

  本文描述了一些硅基单体，这些单体能够在水介质中与其他单体接触时形成生物上有用的多聚体。这种多聚体形成的单体关联可以通过单体与其目标生物分子的近距离结合来促进。在一个方面，这样的单体可以在水介质（例如体内）中与另一个单体结合形成多聚体（例如二聚体）。考虑的单体可能包括配体部分、连接元素和连接配体部分和连接元素的连接器元素。在水介质中，这样的单体可以通过每个连接器元素连接在一起，因此可以同时调节一个或多个生物分子，例如调节蛋白质上的两个或更多结合域或不同蛋白质上的结合域。
• Silyl monomers capable of multimerizing in an aqueous solution, and methods of using same
  申请人：Cornell University

  公开号：US10912786B2

  公开（公告）日：2021-02-09

  Described herein are silyl monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. Such multimer forming associations of monomers may be promoted by the proximal binding of the monomers to their target biomolecule(s). In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.

  本文所述的硅烷基单体在水介质中与一种、两种、三种或更多种其它单体接触时，能够形成具有生物作用的多聚体。单体与目标生物分子的近端结合可促进单体之间形成这种多聚体关联。在一个方面，这种单体可以在水介质中（如体内）与另一种单体结合形成多聚体（如二聚体）。可考虑的单体包括配体分子、连接体元件以及连接配体分子和连接体元件的连接体元件。在水性介质中，这种设想的单体可通过每个连接体元件连接在一起，因此可基本同时调节一种或多种生物分子，例如调节一种蛋白质或不同蛋白质上的两个或多个结合域。