(2S)-2-[2-(4-aminophenyl)ethyl]azepane-1-carbothioic S-acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-2-[2-(4-aminophenyl)ethyl]azepane-1-carbothioic S-acid
• 化学式: C₁₅H₂₂N₂OS
• 分子量: 278.4
• InChiKey: OASKDQTYJDXRDX-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  47.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Non-competitive immunoassays to detect small molecules using nanopeptamers
  申请人：The Regents of the University of California

  公开号：US10101324B2

  公开（公告）日：2018-10-16

  A method for noncompetitive detection of a small analyte using nanopeptamers, and devices useful for performing the methods. Nanopeptamers include a self-associating oligomeric protein that is attached to peptides that bind to an immune complex between the target analyte and a capture antibody. The noncompetitive methods allow for the direct detection of small analytes with increased sensitivity over competitive methods directed to the same target analyte, and provide a positive readout which is useful for rapid tests and on-site detection of small analytes such as such as pesticides, persistent organic pollutants, explosives, toxins, medicinal and abused drugs, and hormones.

  一种利用纳米肽对小型分析物进行非竞争性检测的方法，以及用于执行该方法的装置。纳米肽包括一种自结合寡聚蛋白，它附着在肽上，肽与目标分析物和捕获抗体之间的免疫复合物结合。与针对相同目标分析物的竞争性方法相比，这种非竞争性方法可直接检测小型分析物，提高灵敏度，并提供阳性读数，有助于快速测试和现场检测小型分析物，如杀虫剂、持久性有机污染物、爆炸物、毒素、药物和滥用药物以及激素。
• NON-COMPETITIVE IMMUNOASSAYS TO DETECT SMALL MOLECULES USING NANOPEPTAMERS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20150309017A1

  公开（公告）日：2015-10-29

  The present invention is directed to noncompetitive methods for detecting small analytes using nanopeptamers, and to devices useful for performing the methods. Nanopeptamers include a self-associating oligomeric protein that is attached to peptides that bind to an immune complex between the target analyte and a capture antibody. The noncompetitive methods allow for the direct detection of small analytes with increased sensitivity over competitive methods directed to the same target analyte, and provide a positive readout which is useful for rapid tests and on-site detection of small analytes such as such as pesticides, persistent organic pollutants, explosives, toxins, medicinal and abused drugs, and hormones.
• [EN] NON-COMPETITIVE IMMUNOASSAYS TO DETECT SMALL MOLECULES USING NANOPEPTAMERS<br/>[FR] DOSAGES IMMUNOLOGIQUES NON COMPÉTITIFS POUR DÉTECTER LES PETITES MOLÉCULES À L'AIDE DE NANOPEPTAMÈRES
  申请人：UNIV CALIFORNIA

  公开号：WO2014088890A1

  公开（公告）日：2014-06-12

  The present invention is directed to noncompetitive methods for detecting small analytes using nanopeptamers, and to devices useful for performing the methods. Nanopeptamers include a self-associating oligomeric protein that is attached to peptides that bind to an immune complex between the target analyte and a capture antibody. The noncompetitive methods allow for the direct detection of small analytes with increased sensitivity over competitive methods directed to the same target analyte, and provide a positive readout which is useful for rapid tests and on-site detection of small analytes such as such as pesticides, persistent organic pollutants, explosives, toxins, medicinal and abused drugs, and hormones.