S-[2-(4-aminophenyl)ethyl] azepane-1-carbothioate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: S-[2-(4-aminophenyl)ethyl] azepane-1-carbothioate
• 化学式: C₁₅H₂₂N₂OS
• 分子量: 278.4
• InChiKey: ABRYAYLXNMNRHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  71.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Non-competitive immunoassays to detect small molecules using nanopeptamers
  申请人：The Regents of the University of California

  公开号：US10101324B2

  公开（公告）日：2018-10-16

  A method for noncompetitive detection of a small analyte using nanopeptamers, and devices useful for performing the methods. Nanopeptamers include a self-associating oligomeric protein that is attached to peptides that bind to an immune complex between the target analyte and a capture antibody. The noncompetitive methods allow for the direct detection of small analytes with increased sensitivity over competitive methods directed to the same target analyte, and provide a positive readout which is useful for rapid tests and on-site detection of small analytes such as such as pesticides, persistent organic pollutants, explosives, toxins, medicinal and abused drugs, and hormones.

  一种利用纳米肽对小型分析物进行非竞争性检测的方法，以及用于执行该方法的装置。纳米肽包括一种自结合寡聚蛋白，它附着在肽上，肽与目标分析物和捕获抗体之间的免疫复合物结合。与针对相同目标分析物的竞争性方法相比，这种非竞争性方法可直接检测小型分析物，提高灵敏度，并提供阳性读数，有助于快速测试和现场检测小型分析物，如杀虫剂、持久性有机污染物、爆炸物、毒素、药物和滥用药物以及激素。
• NON-COMPETITIVE IMMUNOASSAYS TO DETECT SMALL MOLECULES USING NANOPEPTAMERS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20150309017A1

  公开（公告）日：2015-10-29

  The present invention is directed to noncompetitive methods for detecting small analytes using nanopeptamers, and to devices useful for performing the methods. Nanopeptamers include a self-associating oligomeric protein that is attached to peptides that bind to an immune complex between the target analyte and a capture antibody. The noncompetitive methods allow for the direct detection of small analytes with increased sensitivity over competitive methods directed to the same target analyte, and provide a positive readout which is useful for rapid tests and on-site detection of small analytes such as such as pesticides, persistent organic pollutants, explosives, toxins, medicinal and abused drugs, and hormones.
• PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS
  申请人：Seattle Children's Hospital (dba Seattle Children's Research Institute)

  公开号：US20200087399A1

  公开（公告）日：2020-03-19

  Aspects of the invention described herein relate to synthetic compounds that are useful for targeting and labeling tumor cells so as to facilitate recognition by binding agents including Chimeric Antigen Receptor T cells (CAR T cells), which are administered to a subject by intravenous or locoregional administration. Several compositions and methods of making and using these compositions to treat or inhibit a disease in a subject are contemplated.
• [EN] NON-COMPETITIVE IMMUNOASSAYS TO DETECT SMALL MOLECULES USING NANOPEPTAMERS<br/>[FR] DOSAGES IMMUNOLOGIQUES NON COMPÉTITIFS POUR DÉTECTER LES PETITES MOLÉCULES À L'AIDE DE NANOPEPTAMÈRES
  申请人：UNIV CALIFORNIA

  公开号：WO2014088890A1

  公开（公告）日：2014-06-12

  The present invention is directed to noncompetitive methods for detecting small analytes using nanopeptamers, and to devices useful for performing the methods. Nanopeptamers include a self-associating oligomeric protein that is attached to peptides that bind to an immune complex between the target analyte and a capture antibody. The noncompetitive methods allow for the direct detection of small analytes with increased sensitivity over competitive methods directed to the same target analyte, and provide a positive readout which is useful for rapid tests and on-site detection of small analytes such as such as pesticides, persistent organic pollutants, explosives, toxins, medicinal and abused drugs, and hormones.
• [EN] PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS<br/>[FR] AGENTS DE CIBLAGE DE TUMEUR À LYMPHOCYTES T CAR (CTCT) D'ÉTHER DE PHOSPHOLIPIDE (PLE)
  申请人：SEATTLE CHILDRENS HOSPITAL DBA SEATTLE CHILDRENS RES INST

  公开号：WO2018148224A1

  公开（公告）日：2018-08-16

  Aspects of the invention described herein relate to synthetic compounds that are useful for targeting and labeling tumor cells so as to facilitate recognition by binding agents including Chimeric Antigen Receptor T cells (CAR T cells), which are administered to a subject by intravenous or locoregional administration. Several compositions and methods of making and using these compositions to treat or inhibit a disease in a subject are contemplated.