1,13-bismaleimido-4,7,10-trioxatridecane | 86099-05-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1,13-bismaleimido-4,7,10-trioxatridecane
• 英文别名: 1-[3-[2-[2-[3-(2,5-Dioxopyrrol-1-yl)propoxy]ethoxy]ethoxy]propyl]pyrrole-2,5-dione
• CAS: 86099-05-0
• 化学式: C₁₈H₂₄N₂O₇
• 分子量: 380.398
• InChiKey: PROZVSYJRWYKBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  27
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  102
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1,13-bismaleimido-4,7,10-trioxatridecane 、 N-benzyloxycarbonyl-DL-cysteine 以 aq. phosphate buffer 为溶剂， 30.0 ℃ 、101.33 kPa 条件下， 以97 %的产率得到
  参考文献：
  名称：

  WO2023/135329

  摘要：

  公开号：
• 作为产物：
  描述：

  在 N,N'-二环己基碳二亚胺 、 1-羟基苯并三唑 作用下， 以 四氢呋喃 为溶剂， 反应 35.0h， 以10.52 g的产率得到1,13-bismaleimido-4,7,10-trioxatridecane
  参考文献：
  名称：

  A Dual-Cure, Solid-State Photoresist Combining a Thermoreversible Diels–Alder Network and a Chain Growth Acrylate Network

  摘要：

  A Die Is Alder (DA) network containing dissolved multiacrylate monomers is demonstrated as a novel two-stage reactive polymer network, with a potential application in self-supporting stereolithography. Initially, a thermoreversible Die Is Alder "scaffold" network is formed, containing unreacted acrylate monomers and photoinitiator. During photopatterning with light at 15 mW/cm(2) from a 365 nm source for 16 s of exposure at either ambient temperature or 70 degrees C, both acrylates and unreacted maleimides polymerize to form a permanent, covalently cross-linked network structure that simultaneously maintains the thermoreversible characteristics afforded by the underlying DA network. Light exposure of a DA network containing between 25 and 50 wt % acrylate monomer resulted in a sharp increase in cross-link density and a 60 degrees C jump in glass transition temperature of the material. As a result of the temperature-dependent DA equilibrium, the temperature of the film during light exposure has dramatic effects on the resulting acrylate conversion (as measured by FT-IR) and mechanical behavior (as measured by DMA) of the complex dynamic network structure. For example, despite the irreversible acrylate network, the rubbery modulus of the material decreases above the glass transition temperature due to the presence of the dynamic thermosensitive DA network. The shape of the modulus curve was also affected by the ratio of DA monomers to acrylate monomers; higher DA monomer content resulted in greater temperature sensitivity of the rubbery modulus in light-exposed films. 3D structures with feature sizes ranging from 50 to 500 pm were produced in geometries such as stacked rectangles and "logpile" structures. In the unexposed regions, free acrylate and maleimide groups were shown to tolerate temperatures as high as 120 degrees C with no premature gel formation observed. Removal of unexposed material during the development step was achieved at 120 degrees C, where the Diels-Alder equilibrium shifts toward the furan and maleimide reactants and the network depolymerizes. Finally, a process was developed for the fabrication of 3D microstructures via layer-by-layer photopatterning. The process is highly repeatable and results in complete elimination of unexposed regions. Additionally, excess quantities of the unexposed mixture may be stored at 4 degrees C for at least several weeks and then reused by heating to 120 degrees C to fully depolymerize the DA network, subsequently using the liquid mixture to make films.

  DOI：

  10.1021/ma500244r

文献信息

• Process for cosmetic treatment of keratin materials
  申请人：L'OREAL

  公开号：US10646428B2

  公开（公告）日：2020-05-12

  The invention relates to a cosmetic treatment process, in particular for caring for or making up keratin materials, comprising the following steps: a) a step of applying, to the keratin materials, a cosmetic composition comprising a compound comprising at least 2 maleimide groups; b) a step of applying a cosmetic composition comprising a compound comprising at least 2 furfuryl groups. The invention also relates to a kit comprising the two compositions, enabling said process to be carried out. The invention also relates to copolymers furfuryl (meth)acrylate, specifically (meth)acrylamide, and addition monomer chosen from polyethylene glycol (meth)acrylates and polydimethylsiloxanes with mono(meth)acryloyloxy end group.

  本发明涉及一种化妆品处理工艺，特别是用于护理或妆点角蛋白材料，包括以下步骤：a) 向角蛋白材料涂抹一种化妆品组合物，该组合物包含至少 2 个马来酰亚胺基团的化合物；b) 涂抹一种化妆品组合物，该组合物包含至少 2 个糠基团的化合物。本发明还涉及一种包含上述两种组合物的试剂盒，使上述工艺得以实施。本发明还涉及(甲基)丙烯酸糠酯共聚物，特别是(甲基)丙烯酰胺，以及从聚乙二醇(甲基)丙烯酸酯和具有单(甲基)丙烯酰氧基末端基团的聚二甲基硅氧烷中选择的添加单体。
• Lithium ion battery including separator coated with fire extinguishing particle
  申请人：HYUNDAI MOTOR COMPANY

  公开号：US10727525B2

  公开（公告）日：2020-07-28

  A lithium ion battery including a core-shell structured fire extinguishing particle is disclosed. When the battery is overheated to a predetermined temperature, a shell of the fire extinguishing particle coated on one surface or both surfaces of a porous separator is melted, a fire extinguishing material disposed in an inner space of the shell is released into an electrolytic solution of the battery, and as a result, it is possible to prevent the battery from being ignited or exploded even though the battery is overheated. Further, the melted shell clogs pores of the porous separator to block lithium ions from moving, such that the battery is blocked from being driven, thereby preventing the battery from being overheated any more.

  本发明公开了一种包括芯壳结构灭火粒子的锂离子电池。当电池过热到预定温度时，涂覆在多孔隔膜的一个表面或两个表面上的灭火粒子外壳熔化，置于外壳内部空间的灭火材料释放到电池的电解液中，因此，即使电池过热，也能防止电池被点燃或爆炸。此外，熔化的外壳会堵塞多孔隔膜的孔隙，阻止锂离子移动，从而阻止电池被驱动，防止电池继续过热。
• Zinc‐Substituted Hemoglobin‐Albumin Cluster as a Porphyrin‐Carrier for Enhanced Photodynamic Therapy
  作者：Taiga Yamada、Maho Katsumi、Kota Ishii、Teruyuki Komatsu

  DOI：10.1002/asia.202400257

  日期：——

  theranostics, serving as a porphyrin carrier. Hemoglobin (Hb) consists of α2β2 tetramer with iron(II)-protoporphyrin IX (heme) bound to each globin. However, heme-removed Hb (apoHb) causes dissociation at αβ interfaces and aggregation under physiological conditions. We synthesized a stable apoHb derivative comprising intramolecular-crosslinked apoHb (apoXHb) and human serum albumin (HSA), apoXHb-HSA3. ApoXHb-HSA3

  Apohemoprotein 专注于治疗诊断学领域，作为卟啉载体。血红蛋白 （Hb） 由α2β2 四聚体和与每个珠蛋白结合的铁 （II）-原卟啉 IX（血红素）组成。然而，血红素去除的 Hb （apoHb） 在生理条件下导致 αβ 界面解离和聚集。我们合成了一种稳定的 apoHb 衍生物，包括分子内交联 apoHb （apoXHb） 和人血清白蛋白 （HSA） apoXHb-HSA3。ApoXHb-HSA3 在生理溶液中不产生聚集体。此外，apoXHb-HSA3 与锌 （II） -原卟啉 IX （ZnP） 重构，生成 ZnXHb-HSA3，一种用于光动力疗法 （PDT） 的有效光敏剂。ZnXHb-HSA3 的光物理性质与锌取代的 XHb （ZnXHb） 相同。使用各种癌细胞系评估细胞摄取行为。ZnXHb-HSA3 在细胞周围释放 ZnP，游离的 ZnP 穿透细胞膜。相比之下，在细胞内未观察到蛋白质单位。ZnXHb-HSA3
• N-(furfural) chitosan hydrogels based on Diels–Alder cycloadditions and application as microspheres for controlled drug release
  作者：Marcelino Montiel-Herrera、Alessandro Gandini、Francisco M. Goycoolea、Neil E. Jacobsen、Jaime Lizardi-Mendoza、Maricarmen Recillas-Mota、Waldo M. Argüelles-Monal

  DOI：10.1016/j.carbpol.2015.03.052

  日期：2015.9

  In this study, chitosan was chemically modified by reductive amination in a two-step process. The synthesis of N-(furfural) chitosan (FC) was confirmed by FT-IR and H-1 NMR analysis, and the degrees of substitution were estimated as 8.3 and 23.8%. The cross-linkable system of bismaleimide (BM) and FC shows that FC shared properties of furan-maleimide chemistry. This system produced non-reversible hydrogel networks by Diels-Alder cycloadditions at 85 degrees C. The system composed of BM and FC (23.8% substitution) generated stronger hydrogel networks than those of FC with an 8.3% degree of substitution. Moreover, the FC-BM system was able to produce hydrogel microspheres. Environmental scanning electron microscopy revealed the surface of the microspheres to be non-porous with small protuberances. In water, the microspheres swelled, increasing their volume by 30%. Finally, microspheres loaded with methylene blue were able to release the dye gradually, obeying second-order kinetics for times less than 600 min. This behavior suggests that diffusion is governed by the relaxation of polymer chains in the swelled state, thus facilitating drug release outside the microspheres. (C) 2015 Elsevier Ltd. All rights reserved.
• PHOTOREACTIVE POLYMER
  申请人：BASF SE

  公开号：US20140073717A1

  公开（公告）日：2014-03-13

  A description is given of a photoreactive polymer preparable by radical polymerization using at least one photoreactive monomer, where the photoreactive monomer has at least one radically polymerizable C—C double bond, at least one hydrophilic group selected from an ethylene glycol group and polyethylene glycol groups having at least 2 ethylene glycol units, and at least one photoreactive group, the photoreactive group being a photoenolizable carbonyl group.