1-Hydroxypyrazole;pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-Hydroxypyrazole;pyridine
• 英文别名: 1-hydroxypyrazole;pyridine
• 化学式: C8H9N3O
• 分子量: 163.18
• InChiKey: UTARVRYPGKYBLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] HISTONE DEMETHYLASE INHIBITORS<br/>[FR] INHIBITEURS DE L'HISTONE DÉMÉTHYLASE
  申请人：QUANTICEL PHARMACEUTICALS INC

  公开号：WO2014089364A1

  公开（公告）日：2014-06-12

  Provided herein are substituted pyrazolylpyridine, pyrazolylpyridazine, and pyrazolylpyrimidine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

  本文提供了替代嘧啶基吡唑啉、嘧啶基吡唑啉和嘧啶基吡咪啉衍生物化合物以及包含这些化合物的药物组合物。这些化合物和组合物对于抑制组蛋白去甲基化酶具有用途。此外，这些化合物和组合物对于治疗癌症，如前列腺癌、乳腺癌、膀胱癌、肺癌和/或黑色素瘤等癌症有用。
• HISTONE DEMETHYLASE INHIBITORS
  申请人：Celgene Quanticel Research, Inc.

  公开号：US20170298044A1

  公开（公告）日：2017-10-19

  The present embodiments provide for substituted triazolylpyridine derivative compounds, and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for modulating the activity of histone demethylase enzymes. Additionally, the subject compounds and compositions are useful for the treatment of cancer or other neoplastic diseases, or maladies associated with abnormal histone demethylase activity. Accordingly, the substituted triazolylpyridine derivative compounds described herein are useful in methods and medicaments for treating cancer.

  本实施例提供了取代的三唑基吡啶衍生物化合物和包含该化合物的制药组合物。所述化合物和组合物适用于调节组蛋白去甲基化酶酶活性。此外，所述化合物和组合物还适用于治疗癌症或其他肿瘤性疾病，或与异常组蛋白去甲基化酶活性相关的疾病。因此，本文所描述的取代的三唑基吡啶衍生物化合物在治疗癌症的方法和药物中非常有用。
• PYRIDINE-PYRAZOLE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS
  申请人：Celgene Quanticel Research, Inc.

  公开号：EP3763367A1

  公开（公告）日：2021-01-13

  Provided herein are substituted pyrazolylpyridine, pyrazolylpyridazine, and pyrazolylpyrimidine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

  本文提供了取代的吡唑基吡啶、吡唑基哒嗪和吡唑基嘧啶衍生物化合物以及包含上述化合物的药物组合物。上述化合物和组合物可用于抑制组蛋白去甲基化酶。此外，所述化合物和组合物还可用于治疗癌症，如前列腺癌、乳腺癌、膀胱癌、肺癌和/或黑色素瘤等。
• Histone demethylase inhibitors
  申请人：Celgene Quanticel Research, Inc.

  公开号：US10150754B2

  公开（公告）日：2018-12-11

  The present embodiments provide for substituted triazolylpyridine derivative compounds, and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for modulating the activity of histone demethylase enzymes. Additionally, the subject compounds and compositions are useful for the treatment of cancer or other neoplastic diseases, or maladies associated with abnormal histone demethylase activity. Accordingly, the substituted triazolylpyridine derivative compounds described herein are useful in methods and medicaments for treating cancer.

  本实施例提供了取代的三唑吡啶衍生物化合物，以及包含所述化合物的药物组合物。所述化合物和组合物有助于调节组蛋白去甲基化酶的活性。此外，所述化合物和组合物还可用于治疗癌症或其他肿瘤性疾病，或与组蛋白去甲基化酶活性异常有关的疾病。因此，本文所述的取代三唑吡啶衍生物化合物可用于治疗癌症的方法和药物中。
• US8987461B2
  申请人：——

  公开号：US8987461B2

  公开（公告）日：2015-03-24