7-(1,2-dimethyl-heptyl)-4,4-dimethyl-1,4-dihydro-2H-thieno[2,3-c]chromen-9-ol | 26622-10-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 7-(1,2-dimethyl-heptyl)-4,4-dimethyl-1,4-dihydro-2H-thieno[2,3-c]chromen-9-ol
• 英文别名: 1,2-dihydro-4,4-dimethyl-9-hydroxy-7-(3-methyl-2-octyl)-4H-thieno[2,3-c] [1]benzopyran；1,4-Dihydro-7-(1,2-dimethylheptyl)-4,4-dimethyl-2H-thieno(2,3-c)(1)benzopyran-9-ol；4,4-dimethyl-7-(3-methyloctan-2-yl)-1,2-dihydrothieno[2,3-c]chromen-9-ol
• CAS: 26622-10-6
• 化学式: C₂₂H₃₂O₂S
• 分子量: 360.561
• InChiKey: PZDFHHSXZRIAEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  54.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-(1,2-dimethyl-heptyl)-4,4-dimethyl-1,4-dihydro-2H-thieno[2,3-c]chromen-9-ol 、 乙酸酐 以there is obtained 9-acetoxy-1,2-dihydro-4,4 -dimethyl-7-(3-methyl-2-octyl)-4H-thieno[2,3-c][1]benzopyran的产率得到9-acetoxy-1,2-dihydro-4,4-dimethyl-7-(3-methyl-2-octyl)-4H-thieno[2,3-c][1]benzopyran
  参考文献：
  名称：

  Intermediates for the preparation of thienobenzopyrans and

  摘要：

  该专利涉及一种新型的噻吩并苯并吡喃和噻吩并苯并噻吩喹啉类化合物，其化学式为##SPC1##其中m和n分别为0、1、2或3，且m+n为2或3；R.sub.1为低碳基；R.sub.2为烷基或环烷基低碳基，R.sub.3为氢、低碳基、低碳酰基、氨基甲酰基、N-低碳基氨基甲酰基、N,N-二低碳基氨基甲酰基、磷酸酯、半琥珀酸或另一种酸的酯、磷酸酯、结构为##EQU1##的二烷基氨基烷基或其酸加成盐，或结构为##EQU2##的二烷基氨基烷酰基或其酸加成盐，其中x为1到6，R.sub.4和R.sub.5为低碳基；低碳基含1到6个碳原子，烷基含1到20个碳原子，环烷基含3到8个环碳原子。该专利还公开了合成这些化合物的新型中间体以及制备这些化合物的方法。

  公开号：

  US03940421A1
• 作为产物：
  描述：

  1,2-Dihydro-9-hydroxy-7-(3-methyl-2-octyl)-4-oxo-4H-thieno-[2,3-c] [1]benzopyran 在 ammonium chloride 、 magnesium 作用下， 以 对甲苯磺酸 、 Petroleum ether 、 苯 为溶剂， 生成 7-(1,2-dimethyl-heptyl)-4,4-dimethyl-1,4-dihydro-2H-thieno[2,3-c]chromen-9-ol
  参考文献：
  名称：

  Method of treating hypertension with, and compositions useful therein

  摘要：

  通过给予1,2-二氢-4,4-二甲基-9-羟基-7-(3-甲基-2-辛基)-4H-噻吩并[2,3-c][1]苯并吡喃或1,2-二氢-5,5-二甲基-10-羟基-8-(3-甲基-2-辛基)-3H,5H-噻吩并[2,3-c][1]苯并吡喃来减少高血压哺乳动物患者的血压的方法。含有1,2-二氢-4,4-二甲基-9-羟基-7-(3-甲基-2-辛基)-4H-噻吩并[2,3-c][1]苯并吡喃或1,2-二氢-5,5-二甲基-10-羟基-8-(3-甲基-2-辛基)-3H,5H-噻吩并[2,3-c][1]苯并吡喃的制药载体分散的制药组合物。

  公开号：

  US03987190A1

文献信息

• Anesthesia methods using benzopyrans and esters thereof as
  申请人：Abbott Laboratories

  公开号：US04025630A1

  公开（公告）日：1977-05-24

  Improved anesthesia methods comprising pretreating a patient to be anesthetized with a benzopyran of formula I ##STR1## wherein, in the C ring, X is NR.sub.1, S, CH.sub.2 or ##STR2## R.sub.1 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, loweralkanoyl, cycloalkyloweralkyl, cycloalkylloweralkanoyl, cycloalkyl, haloloweralkyl, haloloweralkenyl, phenylloweralkyl, phenyloweralkenyl or phenyloweralkylnyl; m is an integer from 0 to 3, n is an integer from 0 to 3 and n + m = 2 or 3; or the C ring is quinuclidine ring ##STR3## R.sub.2 is loweralkyl; R.sub.3 is hydrogen or ##STR4## wherein Y is a straight or branched chain alkylene group having from one to eight carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4, Z is CH.sub.2, O, S or NR.sub.6, R.sub.6 being hydrogen or loweralkyl, with the limitation that when Z is O, S or NR.sub.5, the sum of a and b is 3 or 4, and R.sub.5 is hydrogen or loweralkyl; R.sub.4 is C.sub.1 -C.sub.20 straight or branched chain alkyl, cycloalkyl, or ##STR5## wherein Y is a straight or branched chain alkylene group having from one to ten carbon atoms, and each R.sub.7, R.sub.8 and R.sub.9 are the same or different members of the group consisting of hydrogen, halo, trifluoromethyl or loweralkyl; and the pharmaceutically acceptable salts thereof, with the limitation that when X is ##STR6## m = 2 and n = 2, R.sub.3 cannot be hydrogen.

  改进的麻醉方法包括使用化学式I的苯并吡喃预处理待麻醉的患者 其中，在C环中，X是NR.sub.1，S，CH.sub.2或##STR2## R.sub.1是氢，低烷基，低烯基，低炔基，低酰基，环烷基低烷基，环烷基低酰基，环烷基，卤代低烷基，卤代低烯基，苯基低烷基，苯基低烯基或苯基低烷基; m是0到3的整数，n是0到3的整数，n + m = 2或3;或C环是喹啉环##STR3## R.sub.2是低烷基; R.sub.3是氢或##STR4##其中Y是具有1至8个碳原子的直链或支链烷基基团，a是1到4的整数，b是1到4的整数，Z是CH.sub.2，O，S或NR.sub.6，R.sub.6为氢或低烷基，限制是当Z为O，S或NR.sub.5时，a和b的总和为3或4，R.sub.5为氢或低烷基; R.sub.4是C.sub.1-C.sub.20直链或支链烷基，环烷基，或##STR5##其中Y是具有1到10个碳原子的直链或支链烷基基团，每个R.sub.7，R.sub.8和R.sub.9是氢，卤素，三氟甲基或低烷基的相同或不同成员;及其药用盐，限制是当X为##STR6##时，m = 2，n = 2，R.sub.3不能是氢。
• Method of treating hypertension with, and compositions useful therein
  申请人：Sharps Associates

  公开号：US03987190A1

  公开（公告）日：1976-10-19

  A method of reducing blood pressure in a hypertensive mammalian patient by administering 1,2-dihydro-4,4-dimethyl-9-hydroxy-7-(3-methyl-2-octyl)-4H-thieno[2,3-c][1 ]benzopyran or 1,2-dihydro-5,5-dimethyl-10-hydroxy-8-(3-methyl-2-octyl)-3H,5H-thiopyrano- 8 2,3-c][1]benzopyran. Pharmaceutical compositions containing 1,2-dihydro-4,4-dimethyl-9-hydroxy-7-(3-methyl-2-octyl)-4H-thieno[2,3-c][1 ]benzopyran or 1,2-dihydro-5,5-dimethyl-10-hydroxy-8-(3-methyl-2-octyl)-3H,5H-thiopyrano[ 2,3-c][1]benzopyran dispersed in a pharmaceutical carrier.

  通过给予1,2-二氢-4,4-二甲基-9-羟基-7-(3-甲基-2-辛基)-4H-噻吩并[2,3-c][1]苯并吡喃或1,2-二氢-5,5-二甲基-10-羟基-8-(3-甲基-2-辛基)-3H,5H-噻吩并[2,3-c][1]苯并吡喃来减少高血压哺乳动物患者的血压的方法。含有1,2-二氢-4,4-二甲基-9-羟基-7-(3-甲基-2-辛基)-4H-噻吩并[2,3-c][1]苯并吡喃或1,2-二氢-5,5-二甲基-10-羟基-8-(3-甲基-2-辛基)-3H,5H-噻吩并[2,3-c][1]苯并吡喃的制药载体分散的制药组合物。
• Drugs derived from cannabinoids. 3. Sulfur analogs, thiopyranobenzopyrans and thienobenzopyrans
  作者：Raj K. Razdan、B. Zitko Terris、G. R. Handrick、Haldean C. Dalzell、H. G. Pars、J. F. Howes、Nicholas P. Plotnikoff、Patrick W. Dodge、Anthony T. Dren

  DOI：10.1021/jm00226a022

  日期：1976.4

  Sulfur analogs of cannabinoids corresponding to DMHP (1) were prepared utilizing the Pechmann condensation between the appropriate keto ester and (5-(1,2-dimethylheptyl)resorcinol, followed by Grignard reaction. Compounds of various structural types (2-6), which had different ring size and position of the sulfur atom substituted in the alicyclic ring, were found to be active CNS agents in pharmacological tests in mice, rats, and dogs. They showed profiles qualitatively similar to those of the nitrogen and carbocyclic analogs. Basic esters of the most interesting parent phenols 2 and 4 were also prepared and tested.
• US3940421A
  申请人：——

  公开号：US3940421A

  公开（公告）日：1976-02-24
• US3946111A
  申请人：——

  公开号：US3946111A

  公开（公告）日：1976-03-23