(4aR,8aS)-3-butoxy-4a-hydroxy-6-phenylsulfanyl-8a,9-dihydro-8H-benzo[f][1,2]benzoxazole-4,5-dione

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (4aR,8aS)-3-butoxy-4a-hydroxy-6-phenylsulfanyl-8a,9-dihydro-8H-benzo[f][1,2]benzoxazole-4,5-dione
• 化学式: C₂₁H₂₁NO₅S
• 分子量: 399.5
• InChiKey: CVJWCPLBIMJXQP-ZSEKCTLFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF
  申请人：President and Fellows of Harvard College

  公开号：US20140163238A1

  公开（公告）日：2014-06-12

  The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.
• US9365493B2
  申请人：——

  公开号：US9365493B2

  公开（公告）日：2016-06-14