(3S)-1-[2-[[(1S,2R)-2-[4-(3-methylphenyl)phenyl]cyclopropyl]amino]ethyl]pyrrolidin-3-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3S)-1-[2-[[(1S,2R)-2-[4-(3-methylphenyl)phenyl]cyclopropyl]amino]ethyl]pyrrolidin-3-amine
• 化学式: C₂₂H₂₉N₃
• 分子量: 335.5
• InChiKey: WCCAPFWGNIPUFL-BDTNDASRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  41.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE OR LYMPHOPROLIFERATIVE DISEASES OR DISORDERS
  申请人：Fyfe Matthew Colin Thor

  公开号：US20140163041A1

  公开（公告）日：2014-06-12

  The present invention relates to methods and compositions for the treatment or prevention of diseases and disorder associated with myeloproliferative and lymphoproliferative disorders. In particular, the invention relates to an LSD1 inhibitor for use in treating or preventing diseases and disorder associated with myeloproliferative and lymphoproliferative disorders.
• LYSINE DEMETHYLASE INHIBITORS FOR THROMBOSIS AND CARDIOVASCULAR DISEASES
  申请人：Maes Tamara

  公开号：US20140296255A1

  公开（公告）日：2014-10-02

  The invention relates to methods and compositions for the treatment or prevention of thrombosis, thrombus formation, a thrombotic event or complication, or a cardiovascular disease or event. In particular, the invention relates to an LSD inhibitor such as a 2-cyclylcyclopropan-1-amine derivative, a phenelzine derivative and a propargylamine derivative, for use in treating or preventing thrombosis, thrombus formation, a thrombotic event or complication, or a cardiovascular disease or event.
• LYSINE DEMETHYLASE INHIBITORS FOR INFLAMMATORY DISEASES OR CONDITIONS
  申请人：Maes Tamara

  公开号：US20140329833A1

  公开（公告）日：2014-11-06

  The invention relates to methods and compositions for the treatment or prevention of inflammation and inflammatory diseases or conditions. In particular, the invention relates to an LSD1 inhibitor, such as a 2-cyclylcylopropan-1-amine derivative, a phenelzine derivative and a propargylamine derivative, for use in treating or preventing inflammation and inflammatory diseases or conditions.
• LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE DISORDERS
  申请人：Oryzon Genomics S.A.

  公开号：US20150232436A1

  公开（公告）日：2015-08-20

  The invention relates to methods and compositions for the treatment or prevention of diseases and disorders associated with myeloproliferative disorders. In particular, the invention relates to an LSD 1 inhibitor for use in treating or preventing Philadelphia chromosome negative myeloproliferative disorders.
• US9908859B2
  申请人：——

  公开号：US9908859B2

  公开（公告）日：2018-03-06