1-(3,5-Dichloro-4-methyl-2-nitrosophenyl)-3-(3,5-dichlorophenyl)urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3,5-Dichloro-4-methyl-2-nitrosophenyl)-3-(3,5-dichlorophenyl)urea
• 英文别名: 1-(3,5-dichloro-4-methyl-2-nitrosophenyl)-3-(3,5-dichlorophenyl)urea
• 化学式: C₁₄H₉Cl₄N₃O₂
• 分子量: 393.0
• InChiKey: XHIKDDKKSPEELA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  70.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• NOVEL MODULATORS OF DEVELOPMENT OF ADIPOCYTE AND CANCER CELLS
  申请人：CITY OF HOPE

  公开号：US20140162996A1

  公开（公告）日：2014-06-12

  One aspect of the disclosure relates to derivatives of aryl and heterocyclic ureido aryl and heterocyclic carboxamido isobutyric acids, dichlorophenyl urea, curcumin, and 1,3-diazetidine-2,4-dione, and pharmaceutical compositions thereof. The derivatives disclosed herein can modulate development of adipocytes and various cancer cells, including resistant cancer cells and cancer stem cells. Another aspect of the disclosure relates to the use of the derivatives and pharmaceutical compositions disclosed herein in treatment of obesity and various cancers.