1-Tert-butyl-3,3-dipropylpyrrolidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-Tert-butyl-3,3-dipropylpyrrolidine
• 英文别名: 1-tert-butyl-3,3-dipropylpyrrolidine
• 化学式: C₁₄H₂₉N
• 分子量: 211.39
• InChiKey: XLFOBEUOXSINSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• NOVEL PYRAZOLE COMPOUNDS
  申请人：Eli Lilly and Company

  公开号：US20140162967A1

  公开（公告）日：2014-06-12

  The present invention provides a compound of Formula II: wherein X represents the following: or a pharmaceutically acceptable salt thereof.

  本发明提供了一个II式化合物，其中X代表以下内容：或其药学上可接受的盐。
• Compound used as Bruton's tyrosine kinase inhibitor and preparation method and application thereof
  申请人：Chengdu Brilliant Pharmaceutical Co., LTD.

  公开号：US10793576B2

  公开（公告）日：2020-10-06

  The present invention provides a compound having a structure shown in formula (I) or an isomer, pharmaceutically acceptable solvate, or salt thereof. The compound is used as a Bruton's tyrosine kinase inhibitor, and has a higher inhibitory activity against BTK and less adverse effects.

  本发明提供了一种具有式（I）所示结构的化合物或其异构体、药学上可接受的溶液或盐。该化合物可用作布鲁顿酪氨酸激酶抑制剂，对 BTK 具有较高的抑制活性，且不良反应较少。
• COMPOUND USED AS BRUTON'S TYROSINE KINASE INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF
  申请人：Chengdu Brilliant Pharmaceutical Co., LTD.

  公开号：US20190315758A1

  公开（公告）日：2019-10-17

  The present invention provides a compound having a structure shown in formula (I) or an isomer, pharmaceutically acceptable solvate, or salt thereof. The compound is used as a Bruton's tyrosine kinase inhibitor, and has a higher inhibitory activity against BTK and less adverse effects.
• US9296775B2
  申请人：——

  公开号：US9296775B2

  公开（公告）日：2016-03-29