Ethyl N-acetyl-4-chlorobenzene-1-carboximidate | 923017-82-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl N-acetyl-4-chlorobenzene-1-carboximidate
• 英文别名: ethyl N-acetyl-4-chlorobenzenecarboximidate
• CAS: 923017-82-7
• 化学式: C₁₁H₁₂ClNO₂
• 分子量: 225.675
• InChiKey: YTNIWHLUAFNRFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Ethyl N-acetyl-4-chlorobenzene-1-carboximidate 、 diethoxyphosphinyl acetic acid hydrazide 以 甲苯 为溶剂， 反应 30.0h， 以62%的产率得到
  参考文献：
  名称：

  Synthese Originale de 5-Aryl (ou 5-benzyl)-2[(1-Diethoxyphosphonyl)methyl]-1,3,4-oxadiazoles par Action du Phosphonomethylhydrazide sur les Imidates N-Acyles

  摘要：

  The phosphonomethylhydrazide 2a reacts with N-acylated imidates 3a-d to give the corresponding 5-aryl (or 5-benzyl)-2-[(1-diethoxyphosphonyl)methyl]-1,3,4-oxadiazoles 4a-d after the elimination of ethanamide 5. Compounds 2a-e are prepared by the action of triethyl phosphonoacetate 1 with hydrazine and its derivatives. The structures of 1,3,4-oxadiazoles 4a-d and hydrazides 2a-e have been unequivocally confirmed by means of IR, H-1, C-13, P-31 NMR and mass spectrometry.

  DOI：

  10.1080/10426500600695047
• 作为产物：
  描述：

  乙酰氯 、 4-chlorobenzimidic acid ethyl ester 在 三乙胺 作用下， 以 乙醚 为溶剂， 反应 12.0h， 以83%的产率得到Ethyl N-acetyl-4-chlorobenzene-1-carboximidate
  参考文献：
  名称：

  Synthese Originale de 5-Aryl (ou 5-benzyl)-2[(1-Diethoxyphosphonyl)methyl]-1,3,4-oxadiazoles par Action du Phosphonomethylhydrazide sur les Imidates N-Acyles

  摘要：

  The phosphonomethylhydrazide 2a reacts with N-acylated imidates 3a-d to give the corresponding 5-aryl (or 5-benzyl)-2-[(1-diethoxyphosphonyl)methyl]-1,3,4-oxadiazoles 4a-d after the elimination of ethanamide 5. Compounds 2a-e are prepared by the action of triethyl phosphonoacetate 1 with hydrazine and its derivatives. The structures of 1,3,4-oxadiazoles 4a-d and hydrazides 2a-e have been unequivocally confirmed by means of IR, H-1, C-13, P-31 NMR and mass spectrometry.

  DOI：

  10.1080/10426500600695047

文献信息

• Synthese Originale de 5-Aryl (ou 5-benzyl)-2[(1-Diethoxyphosphonyl)methyl]-1,3,4-oxadiazoles par Action du Phosphonomethylhydrazide sur les Imidates <i>N</i>-Acyles
  作者：Abdallah Harizi

  DOI：10.1080/10426500600695047

  日期：2006.10.1

  The phosphonomethylhydrazide 2a reacts with N-acylated imidates 3a-d to give the corresponding 5-aryl (or 5-benzyl)-2-[(1-diethoxyphosphonyl)methyl]-1,3,4-oxadiazoles 4a-d after the elimination of ethanamide 5. Compounds 2a-e are prepared by the action of triethyl phosphonoacetate 1 with hydrazine and its derivatives. The structures of 1,3,4-oxadiazoles 4a-d and hydrazides 2a-e have been unequivocally confirmed by means of IR, H-1, C-13, P-31 NMR and mass spectrometry.