4-(2,2-dioxido-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazol-1(3H)-yl)-N-methylbutan-1-amine | 1033220-59-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2,2-dioxido-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazol-1(3H)-yl)-N-methylbutan-1-amine
• 英文别名: 4-(2,2-dioxido-3-phenyl-2,1,3-benzothiadiazol-1(3H)-yl)-N-methylbutan-1-amine；4-(2,2-dioxo-3-phenyl-2λ6,1,3-benzothiadiazol-1-yl)-N-methylbutan-1-amine
• CAS: 1033220-59-5
• 化学式: C₁₇H₂₁N₃O₂S
• 分子量: 331.439
• InChiKey: VKFIVBQTGGJAMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  61
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-(2,2-dioxido-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazol-1(3H)-yl)-N-methylbutan-1-amine 在 盐酸 作用下， 以 乙醚 为溶剂， 生成 4-(2,2-dioxido-3-phenyl-2,1,3-benzothiadiazol-1(3H)-yl)-N-methylbutan-1-amine hydrochloride
  参考文献：
  名称：

  WO2008/73459

  摘要：

  公开号：
• 作为产物：
  描述：

  1-(4-bromobutyl)-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 、 甲胺 在 crude product 、 silica 、 甲醇 、 氨 、 氯仿 作用下， 以 甲醇 为溶剂， 反应 16.0h， 以to give 110 mg of 4-(2,2-dioxido-3-phenyl-2,1,3-benzothiadiazol-1(3H)-yl)-N-methylbutan-1-amine的产率得到4-(2,2-dioxido-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazol-1(3H)-yl)-N-methylbutan-1-amine
  参考文献：
  名称：

  AMINOALKYL SUBSTITUTED ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE

  摘要：

  本发明涉及公式I的氨基烷基取代芳基磺酰胺衍生物，或其药学上可接受的盐、立体异构体或互变异构体，它们是单胺再摄取抑制剂，包含这些衍生物的组合物，以及它们用于预防和治疗症状，包括但不限于血管运动症状、性功能障碍、胃肠障碍和泌尿生殖障碍、抑郁症、内源性行为障碍、认知障碍、糖尿病神经病变、疼痛和其他疾病或障碍的方法。

  公开号：

  US20080161366A1

文献信息

• AMINOALKYL SUBSTITUTED ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE
  申请人：McComas Casey Cameron

  公开号：US20080161366A1

  公开（公告）日：2008-07-03

  The present invention is directed to aminoalkyl-substituted aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

  本发明涉及公式I的氨基烷基取代芳基磺酰胺衍生物，或其药学上可接受的盐、立体异构体或互变异构体，它们是单胺再摄取抑制剂，包含这些衍生物的组合物，以及它们用于预防和治疗症状，包括但不限于血管运动症状、性功能障碍、胃肠障碍和泌尿生殖障碍、抑郁症、内源性行为障碍、认知障碍、糖尿病神经病变、疼痛和其他疾病或障碍的方法。
• METHOD FOR THE FABRICATION OF HIGH SURFACE AREA RATIO AND HIGH ASPECT RATIO SURFACES ON SUBSTRATES
  申请人：National Center for Scientific Research Demokritos

  公开号：EP1937757B1

  公开（公告）日：2018-10-17
• ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE
  申请人：Wyeth

  公开号：EP2061776A1

  公开（公告）日：2009-05-27
• Method For the Fabrication of High Surface Area Ratio and High Aspect Ratio Surfaces on Substrates
  申请人：Tserepi Angeliki

  公开号：US20080296260A1

  公开（公告）日：2008-12-04

  This invention provides a method for the fabrication of surfaces of high surface area ratio on polymeric/plastic materials, and their application in the control of the wetting properties of surfaces, of the transport of liquids on such fabricated surfaces, or of the separation of liquids in microchannels of said surfaces. The fabrication of surfaces of high surface area ratio comprises the following steps: (a) selection of a polymer/plastic layer which contains two or more components differing in their plasma etching behaviour (b) exposure of said polymer/plastic layer to an etching plasma to provide selective removal of one polymer component versus a second plasma-resistant component so as to result in a randomly rough columnar-like surface. In addition, exposure of the said surface to an oxidizing plasma or to a fluorocarbon. depositing plasma renders the surface fully hydrophilic or en super-hydrophobic, respectively.
• [EN] METHOD FOR THE FABRICATION OF HIGH SURFACE AREA RATIO AND HIGH ASPECT RATIO SURFACES ON SUBSTRATES<br/>[FR] PROCÉDÉ DE FABRICATION DE SURFACES DE SUBSTRAT POSSÉDANT UN RAPPORT DE SURFACE ET UN RAPPORT LARGEUR-LONGUEUR ÉLEVÉS
  申请人：NAT CT SCIENT RES DEMOKRITOS

  公开号：WO2007031799A1

  公开（公告）日：2007-03-22

  [EN] This invention provides a method for the fabrication of surfaces of high surface area ratio on polymeric/plastic materials, and their application in the control of the wetting properties of surfaces, of the transport of liquids on such fabricated surfaces, or of the separation of liquids in microchannels of said surfaces. The fabrication of surfaces of high surface area ratio comprises the following steps : (a) selection of a polymer/plastic layer which contains two or more componenets differing in their plasma etching behaviour (b) exposure of said polymer/plastic layer to an etching plasma to provide selective removal of one polymer component versus a second plasma-resistant component so as to result in a randomly rough columnar-like surface. In addition, exposure of the said surface to an oxidizing plasma or to a fluorocarbon. depositing plasma renders the surface fully hydrophilic or super-hydrophobic, respectively.
  [FR] La présente invention concerne un procédé de fabrication de surfaces possédant un rapport de surface élevé sur des matériaux polymères/plastiques, et leur application lors du contrôle des propriétés de mouillage des surfaces, du transport de liquides sur de telles surfaces ainsi obtenues, ou de la séparation de liquides dans des microcanaux desdites surfaces. La fabrication de surfaces possédant un rapport de surface élevé comprend les étapes suivantes : (a) la sélection d'une couche polymère/plastique qui contient deux composants ou plus qui diffèrent quant à leur comportement lors d'une gravure au plasma ; (b) l'exposition de ladite couche de polymère/plastique à un plasma gravant afin de retirer sélectivement l'un des composants polymères contre un second composant résistant au plasma ce qui permet d'obtenir une surface en forme de colonne aléatoirement irrégulière. En outre, l'exposition de ladite surface à un plasma oxydant ou à un plasma déposant du fluorocarbure rend la surface respectivement complètement hydrophile ou extrêmement hydrophobe.