N-[4-[2-(cyclopropylmethylamino)cyclopropyl]phenyl]-1H-pyrazole-4-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-[2-(cyclopropylmethylamino)cyclopropyl]phenyl]-1H-pyrazole-4-carboxamide
• 化学式: C₁₇H₂₀N₄O
• 分子量: 296.37
• InChiKey: QFPJIADUFBUYDU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  69.8
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Methods to determine KDM1A target engagement and chemoprobes useful therefor
  申请人：Oryzon Genomics S.A.

  公开号：US11034991B2

  公开（公告）日：2021-06-15

  The invention relates to methods to determine KDM1A target engagement and chemoprobes useful therefor. In particular, the invention relates to non-peptidic KDM1A chemoprobes carrying a tag or label that can be used to assess KDM1A target engagement in cells and tissues. These chemoprobes can also be used to identify KDM1A interacting factors and analyze expression levels of KDM1A.

  本发明涉及确定 KDM1A 靶点接合的方法以及对其有用的化学试剂。特别是，本发明涉及携带标记或标签的非肽 KDM1A 化学试剂，可用于评估细胞和组织中的 KDM1A 靶向接合。这些化学试剂还可用于鉴定 KDM1A 的相互作用因子和分析 KDM1A 的表达水平。
• CYCLOPROPANEAMINE COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2743256B1

  公开（公告）日：2018-06-27
• BIOMARKERS ASSOCIATED WITH LSD1 INHIBITORS AND USES THEREOF
  申请人：Oryzon Genomics, S.A.

  公开号：US20180284095A1

  公开（公告）日：2018-10-04

  The invention relates to biomarkers associated with LSD1 inhibitors and uses thereof to assess target engagement and to follow patient response to treatment. The invention further relates to novel therapeutic uses for LSD1 inhibitors based on said biomarkers.
• METHODS TO DETERMINE KDM1A TARGET ENGAGEMENT AND CHEMOPROBES USEFUL THEREFOR
  申请人：Oryzon Genomics S.A.

  公开号：US20190085372A1

  公开（公告）日：2019-03-21

  The invention relates to methods to determine KDM1A target engagement and chemoprobes useful therefor. In particular, the invention relates to non-peptidic KDM1A chemoprobes carrying a tag or label that can be used to assess KDM1A target engagement in cells and tissues. These chemoprobes can also be used to identify KDM1A interacting factors and analyze expression levels of KDM1A.
• US9278931B2
  申请人：——

  公开号：US9278931B2

  公开（公告）日：2016-03-08