Methyl 2-[anilino(pyridin-2-yl)methyl]prop-2-enoate | 1190585-91-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Methyl 2-[anilino(pyridin-2-yl)methyl]prop-2-enoate
• CAS: 1190585-91-1
• 化学式: C₁₆H₁₆N₂O₂
• 分子量: 268.315
• InChiKey: JIVJPIVQKJZNTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  methyl 2-(acetoxy(pyridin-2-yl)methyl)acrylate 、 苯胺 在 三乙烯二胺 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 3.75h， 以85%的产率得到Methyl 2-[anilino(pyridin-2-yl)methyl]prop-2-enoate
  参考文献：
  名称：

  Accelerated Amination of Baylis–Hillman Acetates Under Ultrasound Irradiation

  摘要：

  The amination of the Baylis-Hillman acetates with primary amines can be dramatically promoted with improved yields and shortened reaction time under ultrasound irradiation. The selected aromatic, heteroaromatic, and aliphatic amines were investigated as the effective candidates for the sonochemical transformation.

  DOI：

  10.1080/00397910903219310

文献信息

• Accelerated Amination of Baylis–Hillman Acetates Under Ultrasound Irradiation
  作者：Shao-Qin Ge、Yun-Yu Hua、Min Xia

  DOI：10.1080/00397910903219310

  日期：2010.6.16

  The amination of the Baylis-Hillman acetates with primary amines can be dramatically promoted with improved yields and shortened reaction time under ultrasound irradiation. The selected aromatic, heteroaromatic, and aliphatic amines were investigated as the effective candidates for the sonochemical transformation.