N-[[(3S)-3-(5-bromo-2-fluorophenyl)-4-(hydroxymethyl)-6-(phenylmethoxymethyl)oxan-3-yl]carbamothioyl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[[(3S)-3-(5-bromo-2-fluorophenyl)-4-(hydroxymethyl)-6-(phenylmethoxymethyl)oxan-3-yl]carbamothioyl]benzamide
• 化学式: C₂₈H₂₈BrFN₂O₄S
• 分子量: 587.5
• InChiKey: TWQRSZBSMHKIFM-QZDZRYIRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] AMINOTHIAZINES AND THEIR USE AS BACE1 INHIBITORS<br/>[FR] AMINOTHIAZINES ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE BACE1
  申请人：LILLY CO ELI

  公开号：WO2018031334A1

  公开（公告）日：2018-02-15

  The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, and the use of compounds of Formula I for treatment of neurodegenerative diseases and disorders, such as Alzheimer's disease.

  本发明提供了一种化合物的化学式I：或其药用可接受的盐，并且提供了化学式I化合物用于治疗神经退行性疾病和紊乱，例如阿尔茨海默病。
• HEXAHYDROPYRANO [3,4-D][1,3]THIAZIN-2-AMINE COMPOUNDS AS INHIBITORS OF BACE1
  申请人：Pfizer Inc.

  公开号：EP2931731A1

  公开（公告）日：2015-10-21
• [EN] HEXAHYDROPYRANO [3,4-D][1,3]THIAZIN-2-AMINE COMPOUNDS AS INHIBITORS OF BACE1<br/>[FR] COMPOSÉS D'HEXAHYDROPYRANO [3,4-D][1,3]THIAZIN-2-AMINE EN TANT QU'INHIBITEURS DE BACE1
  申请人：PFIZER

  公开号：WO2014091352A1

  公开（公告）日：2014-06-19

  The present invention provides compounds of Formula (I), and the tautomers thereof, and the pharmaceutically acceptable salts of the compounds and tautomers, wherein the compounds have the structure (I) wherein the variables R1, R2, R3, R4 and x are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.