4-(methylamino)-2-methylsulfanyl-6H-pyrimido[4,5-d]pyrimidin-5-one

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-(methylamino)-2-methylsulfanyl-6H-pyrimido[4,5-d]pyrimidin-5-one
• 化学式: C₈H₉N₅OS
• 分子量: 223.26
• InChiKey: RKRVWKQHQBXTCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• BICYCLIC INHIBITORS OF ALK
  申请人：Vasudevan Anil

  公开号：US20140171429A1

  公开（公告）日：2014-06-19

  The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, Formula (1) wherein R 1 , R 2 , R 3 , X, Y, Z, A, B, G 1 , m, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

  本发明涉及式(1)的化合物或药用可接受的盐，式(1)中R1、R2、R3、X、Y、Z、A、B、G1、m和n的定义在说明中。本发明还涉及含有所述化合物的组合物，用于抑制激酶如ALK以及治疗癌症等疾病的方法。
• HETEROARYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH PI3 KINASES, CONTAINING SAME AS ACTIVE INGREDIENT
  申请人：Korea Research Institute of Chemical Technology

  公开号：EP3312175A1

  公开（公告）日：2018-04-25

  The present invention relates to a heteroaryl derivative or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition for preventing or treating diseases associated with PI3 kinases, containing the same as an active ingredient. The heteroaryl derivative according to the present invention has an excellent effect of selectively inhibiting PI3 kinases, thereby being useful in preventing or treating PI3 kinase diseases such as: cancers such as hematologic malignancy, ovarian cancer, uterine cervical cancer, breast cancer, colorectal cancer, liver cancer, gastric cancer, pancreatic cancer, colon cancer, peritoneal metastatic cancer, skin cancer, bladder cancer, prostate cancer, lung cancer, osteosarcoma, fibrous tumors, and brain tumors; autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosis, multiple sclerosis, diabetes mellitus, hyperthyroidism, myasthenia, Crohn's disease, ankylosing spondylitis, autoimmune pernicious anemia, and Sjogren's syndrome; and respiratory diseases such as chronic obstructive pulmonary disease (COPD), rhinitis, asthma, chronic bronchitis, chronic pulmonary inflammatory diseases, silicosis, pulmonary sarcoidosis, pleurisy, alveolitis, angitis, pneumatosis, pneumonia, and bronchiectasis.

  本发明涉及一种杂芳基衍生物或其药学上可接受的盐、其制备方法以及一种用于预防或治疗与PI3激酶相关疾病的药物组合物，其中含有杂芳基衍生物或其药学上可接受的盐、其制备方法以及一种用于预防或治疗与PI3激酶相关疾病的药物组合物，其中含有杂芳基衍生物或其药学上可接受的盐作为活性成分。根据本发明的杂芳基衍生物具有很好的选择性抑制 PI3 激酶的效果，因此可用于预防或治疗 PI3 激酶疾病，如癌症，如血液系统恶性肿瘤、卵巢癌、子宫颈癌、乳腺癌、结直肠癌、肝癌、胃癌、胰腺癌、结肠癌、腹膜转移癌、皮肤癌、膀胱癌、前列腺癌、肺癌、骨肉瘤、纤维瘤和脑瘤；自身免疫性疾病，如类风湿性关节炎、系统性红斑狼疮、多发性硬化症、糖尿病、甲状腺机能亢进症、肌无力、克罗恩病、强直性脊柱炎、自身免疫性恶性贫血和 Sjogren 综合征；呼吸系统疾病，如慢性阻塞性肺病（COPD）、鼻炎、哮喘、慢性支气管炎、慢性肺部炎症、矽肺、肺肉瘤病、胸膜炎、肺泡炎、血管炎、肺气肿、肺炎和支气管扩张。