[4-[2-(Tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenyl] 5-[[8-[3-[2-(2-methoxyethoxy)ethoxy]propanoylamino]-3-oxooctan-4-yl]amino]-5-oxopentanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: [4-[2-(Tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenyl] 5-[[8-[3-[2-(2-methoxyethoxy)ethoxy]propanoylamino]-3-oxooctan-4-yl]amino]-5-oxopentanoate
• 英文别名: [4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenyl] 5-[[8-[3-[2-(2-methoxyethoxy)ethoxy]propanoylamino]-3-oxooctan-4-yl]amino]-5-oxopentanoate
• 化学式: C₃₄H₅₇N₃O₁₀
• 分子量: 667.8
• InChiKey: PLTKIQCTEAHZTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  47
• 可旋转键数：
  28
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  182
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• MACROMOLECULES
  申请人：Owen David

  公开号：US20140171375A1

  公开（公告）日：2014-06-19

  The present invention relates to a macromolecule comprising a dendrimer having surface amino groups to which at least two different terminal groups are attached including a pharmaceutically active agent and a pharmacokinetic modifying agent, the pharmaceutically active agent comprising a hydroxyl group and being attached to the surface amino group of the dendrimer through a diacid linker. Pharmaceutical compositions comprising the macromolecules and methods of treatment using the macromolecules are also described.
• US9744246B2
  申请人：——

  公开号：US9744246B2

  公开（公告）日：2017-08-29