2,2-Dimethylpropyl-dimethyl-[(4-methylphenyl)methyl]azanium

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2-Dimethylpropyl-dimethyl-[(4-methylphenyl)methyl]azanium
• 英文别名: 2,2-dimethylpropyl-dimethyl-[(4-methylphenyl)methyl]azanium
• 化学式: C15H26N+
• 分子量: 220.37
• InChiKey: STUGWXGVWOYTMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• AZOLE HETEROCYCLIC COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE
  申请人：Shen Jianhua

  公开号：US20140171431A1

  公开（公告）日：2014-06-19

  The present invention relates to the field of pharmaceutical chemistry, and in particular, to a novel class of azole compounds represented by general formula (I), (II) or (III) and a preparation method thereof, a pharmaceutical composition with the compounds as active components, and a use of the azole compounds and the pharmaceutical composition in the preparation of a medicament for treatment of diseases associated with Lp-PLA 2 enzyme activities, wherein each substituent is as defined in the specification.

  本发明涉及制药化学领域，特别是一种由通式（I）、（II）或（III）表示的新型类唑化合物，以及其制备方法，以这些化合物为活性成分的药物组合物，以及在制备用于治疗与Lp-PLA2酶活性相关疾病的药物中使用这些唑化合物和药物组合物的用途，其中每个取代基如规范中定义。
• ORGANIC SYNTHESIS APPLICATIONS OF NON-AQUEOUS FLUORIDE SALT SOLUTIONS
  申请人：CALIFORNIA INSTITUTE OF TECHNOLOGY

  公开号：US20170057908A1

  公开（公告）日：2017-03-02

  Processes and reaction mixtures including non-aqueous solvent mixtures are presented. Non-aqueous solvent mixtures including fluoride salt and non-aqueous solvent combinations are provided that possess high fluoride ion concentrations useful for a range of applications, including organic synthesis. Further non-aqueous solvent mixtures are provided including a salt possessing a non-fluoride anion and a non-aqueous solvent that, when contacted with aqueous fluoride-containing reagents, extract fluoride ions to form non-aqueous fluoride-ion solutions possessing high fluoride-ion concentrations. The salts include an organic cation that does not possess a carbon in the β-position or does not possess a carbon in the β-position having a bound hydrogen. This salt structure facilitates its ability to be made anhydrous without decomposition. Example anhydrous fluoride salts include (2,2-dimethylpropyl)trimethylammonium fluoride and bis(2,2-dimethylpropyl)dimethylammonium fluoride. The combination of these fluoride salts with at least one fluorine-containing non-aqueous solvent (e.g., bis(2,2,2-trifluoroethyl)ether; (BTFE)) promotes solubility of the salt within the non-aqueous solvents.

  提供了包括非水溶剂混合物的过程和反应混合物。提供了包括氟化物盐和非水溶剂组合的非水溶剂混合物，其具有高氟离子浓度，可用于一系列应用，包括有机合成。还提供了包括具有非氟离子的盐和非水溶剂的非水溶剂混合物，当与含氟化物的水溶试剂接触时，提取氟离子以形成具有高氟离子浓度的非水溶性氟离子溶液。这些盐包括一个有机阳离子，该阳离子在β位不含碳或在β位含有结合氢的碳。这种盐的结构有助于使其在无水条件下不分解。例如，无水氟化物盐包括(2,2-二甲基丙基)三甲基铵氟化物和双(2,2-二甲基丙基)二甲基铵氟化物。这些氟化物盐与至少一种含氟非水溶剂（例如双(2,2,2-三氟乙基)醚；(BTFE)）的组合促进了盐在非水溶剂中的溶解度。