(3S,4R)-3-hydroxy-4-methyl-6-(2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl)-6-oxohexanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (3S,4R)-3-hydroxy-4-methyl-6-(2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl)-6-oxohexanamide
• 化学式: C₁₄H₂₅N₃O₃
• 分子量: 283.37
• InChiKey: FEKGXPPGHILGBR-YYJSSNLHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  86.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• NOVEL PHARMACEUTICAL FORMULATIONS AND THEIR USE IN THE TREATMENT OF PERIODONTAL DISEASE
  申请人：PERIOC LTD

  公开号：US20150313959A1

  公开（公告）日：2015-11-05

  The present invention relates to novel treatments of periodontal disease by administering a suitable formulation of a cyclophilin inhibitor. The present invention further relates to novel pharmaceutical compositions containing said cyclophilin inhibitor compounds.
• US9895412B2
  申请人：——

  公开号：US9895412B2

  公开（公告）日：2018-02-20
• [EN] NOVEL PHARMACEUTICAL FORMULATIONS AND THEIR USE IN THE TREATMENT OF PERIODONTAL DISEASE<br/>[FR] NOUVELLES FORMULATIONS PHARMACEUTIQUES ET LEUR UTILISATION DANS LE TRAITEMENT D'UNE MALADIE PARODONTALE
  申请人：PERIOC LTD

  公开号：WO2014091239A1

  公开（公告）日：2014-06-19

  The present invention relates to novel treatments of periodontal disease by administering a suitable formulation of a cyclophilin inhibitor. The present invention further relates to novel pharmaceutical compositions containing said cyclophilin inhibitor compounds.