1H-imidazole;pyridine;hydrate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1H-imidazole;pyridine;hydrate
• 化学式: C8H11N3O
• 分子量: 165.19
• InChiKey: XJCYYTKYZQMBGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.67
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Nanostructured Biomimetic Device with Contour Map of Multiple Variable Correlation Method to Visually Display the Cancer Progresses
  申请人：Chen Ellen T.

  公开号：US20140178925A1

  公开（公告）日：2014-06-26

  The present invention provides a novel electrochemical device and a cancer cell heat release map method to visually display the cancer progresses. The novel device comprises an electrode having a nanopore biomimetic electron-relay network with imidazolium-ATP of cancer cell-water-pyridine at the active sites that mimic the electron-relaying between His 516 and N(5)-FAD of GOx for the purpose to selectively detect triple-negative breast cancer cell at single cell concentration and it rejects brain cancer cell. The device is fast in millisecond to detect cancers without sample preparation and without interference from other substances, such glucose and proteins under reagent-free conditions. A unique biomarker of the ratio of “Action/Resting” cell membrane potential can be used to monitor the cancer progress against the normal cells. A visual contour map of a multiple variable correlation method provided to assess the heat release from the cancer cells against the normal cells is presented. The device for a potential therapeutic application was demonstrated by discharge voltage pulses from the live cancer cells with release extra energy that the cells possessed until it returns to a normal status in terms of normal cell membrane action/resting potential ratio.
• Nanostructured Biomimetic Devices of Making and Its Therapeutic Applications Thereto
  申请人：Chen ELLEN T.

  公开号：US20170164886A1

  公开（公告）日：2017-06-15

  The present invention provides a handheld electrochemical cancer monitoring and therapeutic device comprising a key component of a sensor compartment comprising an electrode with a substrate having a nanostructured biomimetic membrane attached thereto and an open window allows the electrode fixed in a socket of the sensor compartment to the window to be contacted to the human breast; in the base of the device there is a window for cancer heat release result displayed in a contour map format when the device applied a fixed current to induce cancer cell's bio-communication with the sensor membrane selectively under noninvasive, antibody-free and reagent-free conditions. Methods for therapeutic function and monitoring of early asymptomatic normal human breast in vivo and therapeutic treatment of breast cancer cell line in vitro are disclosed.
• US9534999B2
  申请人：——

  公开号：US9534999B2

  公开（公告）日：2017-01-03