2-[5-[[3,6-Bis[(4-fluorophenyl)sulfanyl]pyridine-2-carbonyl]amino]thiophen-2-yl]sulfanylacetic acid

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-[5-[[3,6-Bis[(4-fluorophenyl)sulfanyl]pyridine-2-carbonyl]amino]thiophen-2-yl]sulfanylacetic acid
• 英文别名: 2-[5-[[3,6-bis[(4-fluorophenyl)sulfanyl]pyridine-2-carbonyl]amino]thiophen-2-yl]sulfanylacetic acid
• 化学式: C₂₄H₁₆F₂N₂O₃S₄
• 分子量: 546.7
• InChiKey: KJGBAUALEBUECK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  183
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF TREATMENT
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US20150336946A1

  公开（公告）日：2015-11-26

  Novel pyridine-2-carboxamide derivatives of formula I and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are effective as glucokinase activating agents. Pharmaceutical compositions and methods of treatment are also included. The present invention relates to novel pyridine-2-carboxamide derivatives and salts thereof which are effective as glucokinase activating agents. Moreover, it relates to compositions containing such compounds, and methods of treatment.

  本发明公开了式I的新型吡啶-2-羧酰胺衍生物及其药学上可接受的盐，用于治疗或预防2型糖尿病和类似疾病。这些化合物作为葡萄糖激酶激活剂具有有效性。本发明还涉及包含这些化合物的制药组合物和治疗方法。本发明涉及新型吡啶-2-羧酰胺衍生物及其盐，其作为葡萄糖激酶激活剂具有有效性。此外，涉及含有此类化合物的组合物和治疗方法。
• US9527838B2
  申请人：——

  公开号：US9527838B2

  公开（公告）日：2016-12-27
• [EN] NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF TREATMENT<br/>[FR] NOUVEAUX DÉRIVÉS DE PYRIDINE -2-CARBOXAMIDE, COMPOSITIONS CONTENANT DE TELS COMPOSÉS ET MÉTHODES DE TRAITEMENT ASSOCIÉES
  申请人：MERCK SHARP & DOHME

  公开号：WO2014099584A1

  公开（公告）日：2014-06-26

  Novel pyridine-2-carboxamide derivatives of formula I and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are effective as glucokinase activating agents. Pharmaceutical compositions and methods of treatment are also included. The present invention relates to novel pyridine-2-carboxamide derivatives and salts thereof which are effective as glucokinase activating agents. Moreover, it relates to compositions containing such compounds, and methods of treatment.