3-(1,3-Thiazol-4-yl)pyridine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(1,3-Thiazol-4-yl)pyridine-2-carboxamide
• 英文别名: 3-(1,3-thiazol-4-yl)pyridine-2-carboxamide
• 化学式: C₉H₇N₃OS
• 分子量: 205.24
• InChiKey: CYLOBOKNPNMPAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  97.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SUBSTITUTED PYRIDINE-2-CARBOXAMIDE COMPOUNDS AS APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS
  申请人：Gilead Sciences, Inc.

  公开号：EP2935258A1

  公开（公告）日：2015-10-28
• APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS
  申请人：Gilead Sciences, Inc.

  公开号：EP3083615A1

  公开（公告）日：2016-10-26
• [EN] SUBSTITUTED PYRIDINE-2-CARBOXAMIDE COMPOUNDS AS APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS<br/>[FR] COMPOSÉS DE PYRIDINE-2-CARBOXAMIDE SUBSTITUÉS EN TANT QU'INHIBITEURS DE KINASE RÉGULATRICE DE SIGNAL D'APOPTOSE
  申请人：GILEAD SCIENCES INC

  公开号：WO2014100541A1

  公开（公告）日：2014-06-26

  The present invention relates to compounds of Formula (I) wherein variables are as defined above. The compounds have apoptosis signal-regulating kinase ("ASKl") inhibitory activity, and are thus useful in the treatment of ASKl -mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, COPD, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver diseases, and neurodegenerative diseases.
• [EN] APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS<br/>[FR] INHIBITEURS DE LA KINASE RÉGULANT LE SIGNAL APOPTOTIQUE
  申请人：GILEAD SCIENCES INC

  公开号：WO2015095059A1

  公开（公告）日：2015-06-25

  The present application relates to compounds having the inhibitory activity to apoptosis signal-regulating kinase (ASK1), thus are thus useful in treating ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, COPD, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver diseases, and neurodegenerative diseases.