(2E)-1-(4-bromophenyl)-3-[(2-fluorophenyl)amino]prop-2-en-1-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2E)-1-(4-bromophenyl)-3-[(2-fluorophenyl)amino]prop-2-en-1-one
• 英文别名: (E)-1-(4-bromophenyl)-3-(2-fluoroanilino)prop-2-en-1-one
• 化学式: C₁₅H₁₁BrFNO
• 分子量: 320.16
• InChiKey: NTXJZQOYBQSUBF-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• TREATMENT OF NEURODEGENERATIVE DISEASES, CAUSATION OF MEMORY ENHANCEMENT, AND ASSAY FOR SCREENING COMPOUNDS FOR SUCH
  申请人：Southern Research Institute

  公开号：US20160022691A1

  公开（公告）日：2016-01-28

  Methods for enhancing memory and/or learning and prevent neurodegeneration by administration of certain heterocyclic and aromatic compounds are described. The methods are particularly useful for treating patients suffering from a neurodegenerative disease such as (without limitation) Alzheimer's, Parkinsons's, and Lou Gehrig's (ALS) disease or memory or learning impairment. A neuronal human cell-based assay that assess NF-kB gene up-regulation using a luciferase reporter is also provided that screens for compounds useful in methods for enhancing memory or learning.
• US9980969B2
  申请人：——

  公开号：US9980969B2

  公开（公告）日：2018-05-29