α-methyldopamine | 66432-25-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-methyldopamine
• 英文别名: (+/-) β-methyldopamine；(+/-)-beta-methyldopamine；4-(β-amino-isopropyl)-pyrocatechol；4-(β-Amino-isopropyl)-brenzcatechin；4-(β-Amino-isopropyl)-resorcin；4-(1-Aminopropan-2-yl)benzene-1,2-diol
• CAS: 66432-25-5；767565-43-5
• 化学式: C₉H₁₃NO₂
• 分子量: 167.208
• InChiKey: IDLSQOHXWOVTGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,4-二甲氧基-beta-甲基苯乙胺 在 盐酸 作用下， 生成 α-methyldopamine
  参考文献：
  名称：

  Phenethylamines. IV. Dimethoxy and Dihydroxyphenyl-n-propylamines (β-Methyl-β-pheńethylamines)¹

  摘要：

  DOI：

  10.1021/ja01264a038

文献信息

• Synthesis and Surface Functionalization of Particles
  申请人：Board of Trustees of The University of Alabama

  公开号：US20140179941A1

  公开（公告）日：2014-06-26

  Provided are methods of controlling the shape and surface chemistry of nanoparticles, particularly ferrite nanoparticles. Methods for preparing non-spherical ferrite nanoparticles, including nanocubes, nanobars, nanoplates, and nanoflowers, are described. Also provided are methods of functionalizing the surface of metal and metal oxide particles. The surface functionalization methods do not require the use of chemical linkers and/or additional reagents, and permit the facile conjugation of a range of molecules, including bioactive agents, to the surface of particles.

  提供了控制纳米颗粒形状和表面化学性质的方法，特别是铁氧体纳米颗粒。描述了制备非球形铁氧体纳米颗粒的方法，包括纳米立方体、纳米棒、纳米板和纳米花。还提供了功能化金属和金属氧化物颗粒表面的方法。表面功能化方法不需要使用化学连接剂和/或额外试剂，并允许轻松地将一系列分子，包括生物活性剂，连接到颗粒表面。
• CATECHOLAMINE DERIVATIVES FOR OBESITY AND NEUROLOGICAL DISORDERS
  申请人：Ye Keqiang

  公开号：US20120022086A1

  公开（公告）日：2012-01-26

  Novel compounds, compositions, and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing a catecholamine backbone and pharmaceutically acceptable salts, prodrugs, and derivatives thereof. Specifically, methods, compositions, and compounds for the treatment of disorders including neurological disorders, neuropsychiatric disorders, and metabolic disorders are provided. For example, a first method is provided of treating or reducing the risk of depression, anxiety, or obesity in a subject, which includes administering to the subject a therapeutically effective amount of the described compounds. A further method of promoting neuroprotection in a subject also is provided, which includes administering to the subject a therapeutically effective amount of the described compounds.

  提供了与TrkB受体激活相关的新型化合物、组合物和方法。这些方法包括在体内或体外给予含有儿茶酚背骨和药学上可接受的盐、前药和衍生物的化合物的治疗有效量。具体提供了用于治疗神经系统疾病、神经精神疾病和代谢性疾病的方法、组合物和化合物。例如，提供了一种用于治疗或减少受试者抑郁、焦虑或肥胖风险的第一种方法，其中包括向受试者给予所述化合物的治疗有效量。还提供了一种促进受试者神经保护的方法，其中包括向受试者给予所述化合物的治疗有效量。
• (METH)ACRYLOYL GROUP-CONTAINING AROMATIC ISOCYANATE COMPOUND AND PRODUCTION PROCESS THEREOF
  申请人：Showa Denko K.K.

  公开号：EP1866357A1

  公开（公告）日：2007-12-19
• (Meth) Acryloyl Group-Containing Aromatic Isocyanate Compound and Production Process Thereof
  申请人：Nozawa Kaneo

  公开号：US20090054543A1

  公开（公告）日：2009-02-26

  A monomer is provided which is excellent in reactivity, can give high heat resistance and high refractive index, and has two or more polymerizable functional groups with different polymerization properties and an aromatic ring in the molecule. An industrial advantageous process for producing the monomer is also provided. The monomer is an aromatic isocyanate compound containing a (meth)acryloyl group, and is represented by Formula (I): wherein R 1 is a single bond or a linear or branched alkylene group of 1 to 5 carbon atoms, R 2 is a hydrogen atom or a methyl group, R 3 is a single bond or a linear or branched alkylene group of 1 to 3 carbon atoms, X is independently a halogen atom or an electron-withdrawing group, m is an integer ranging from 0 to 4, n is an integer ranging from 1 to 3, and 1≦m+n≦5.
• US8044235B2
  申请人：——

  公开号：US8044235B2

  公开（公告）日：2011-10-25