6-[2-[3,5-bis(trifluoromethyl)phenyl]-5-(hydroxymethyl)pyrrolidine-1-carbonyl]-1H-pyridin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 6-[2-[3,5-bis(trifluoromethyl)phenyl]-5-(hydroxymethyl)pyrrolidine-1-carbonyl]-1H-pyridin-2-one
• 化学式: C₁₉H₁₆F₆N₂O₃
• 分子量: 434.3
• InChiKey: UTRVVAHNCHHPQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• NOVEL TRICYCLIC 3,4-DIHYDRO-2H-PYRIDO[1,2-A]PYRAZINE-1,6-DIONE DERIVATIVES AS GAMMA SECRETASE MODULATORS
  申请人：Janssen Pharmaceutica NV

  公开号：EP2953949B1

  公开（公告）日：2016-09-28
• NOVEL TRICYCLIC 3,4-DIHYDRO-2H-PYRIDO[1,2-a]PYRAZINE-1,6-DIONE DERIVATIVES AS GAMMA SECRETASE MODULATORS
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：US20150307496A1

  公开（公告）日：2015-10-29

  The present invention is concerned with novel tricyclic 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione derivatives of Formula (I) wherein R 1 , R 2 , R 3 , R 4 , L, Y, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
• [EN] NOVEL TRICYCLIC 3,4-DIHYDRO-2H-PYRIDO[1,2-α]PYRAZINE-1,6-DIONE DERIVATIVES AS GAMMA SECRETASE MODULATORS<br/>[FR] DÉRIVÉS D'UN NOUVEAU TYPE DE 3,4-DIHYDRO-2H-PYRIDO[1,2-&Agr;]PYRAZINE-1,6-DIONE TRICYCLIQUE EN TANT QUE MODULATEURS DE LA GAMMA SÉCRÉTASE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2014096212A1

  公开（公告）日：2014-06-26

  The present invention is concerned with novel tricyclic 3,4-dihydro-2H-pyrido[l,2-a]pyrazine-l,6-dione derivatives of Formula (I) wherein R1, R2, R3, R4, L, Y, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament for the treatment of i.a. Alzheimer's disease.