[(1S,6R,9S)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-8-yl]methyl 4-methylbenzenesulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(1S,6R,9S)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-8-yl]methyl 4-methylbenzenesulfonate
• 化学式: C₁₉H₂₆O₈S
• 分子量: 414.5
• InChiKey: CTGSZKNLORWSMQ-LAYQYYCJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  97.9
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] CONJUGATES OF A GLYCOPROTEIN OR A GLYCAN WITH A TOXIC PAYLOAD<br/>[FR] CONJUGUÉS D'UNE GLYCOPROTÉINE OU D'UN GLYCANE AVEC UNE CHARGE TOXIQUE
  申请人：GLYKOS FINLAND OY

  公开号：WO2014177771A1

  公开（公告）日：2014-11-06

  The invention relates to a glycoprotein-toxic pay- load molecule conjugate, a toxic payload molecule- glycan conjugate, and a pharmaceutical composi- tion.The invention further relates to a method for preparing the glycoprotein-toxic payload mole- cule conjugate, the method for modulating growth of a cell population and a method of treating tu- mour cells.

  这项发明涉及一种糖蛋白-毒性载荷分子结合物、一种毒性载荷分子-糖基结合物和一种药物组合物。该发明还涉及一种制备糖蛋白-毒性载荷分子结合物的方法，一种调节细胞群体生长的方法以及一种治疗肿瘤细胞的方法。
• CONJUGATES OF A GLYCOPROTEIN OR A GLYCAN WITH A TOXIC PAYLOAD
  申请人：GLYKOS FINLAND OY

  公开号：US20160106860A1

  公开（公告）日：2016-04-21

  The invention relates to a glycoprotein-toxic payload molecule conjugate, a toxic payload molecule-glycan conjugate, and a pharmaceutical composition. The invention further relates to a method for preparing the glycoprotein-toxic payload molecule conjugate, the method for modulating growth of a cell population and a method of treating tumour cells.

  本发明涉及一种糖蛋白-毒素荷载分子结合物、毒素荷载分子-糖基结合物和制药组合物。本发明还涉及一种制备糖蛋白-毒素荷载分子结合物的方法，一种调节细胞种群生长的方法和一种治疗肿瘤细胞的方法。
• LINKER-PAYLOAD MOLECULE CONJUGATES
  申请人：GLYKOS FINLAND OY

  公开号：US20150314007A1

  公开（公告）日：2015-11-05

  The invention relates to novel linker-payload molecule conjugates. The invention also relates to novel cell binder-linker-payload molecule conjugates, in particular antibody conjugates of dolastatin or auristatin derivatives.
• Payload-Polymer-Protein Conjugates
  申请人：Glykos Finland Oy

  公开号：US20170189549A1

  公开（公告）日：2017-07-06

  The present invention relates to a conjugate represented by the formula [D-L-Y—(CH2) n -O] m —P-T wherein T is a protein; P is a polymer selected from the group consisting of dextran, mannan, pullulan, hyaluronic acid, hydroxyethyl starch, chondroitin sulphate, heparin, heparin sulphate, polyalkylene glycol, Ficoll, polyvinyl alcohol, amylose, amylopectin, chitosan, cyclodextrin, pectin and carrageenan, or a derivative thereof; m is at least 1; n is in the range of 1 to 10; each Y is independently selected from the group consisting of S, NH and 1,2,3-triazolyl, wherein 1,2,3-triazolyl is optionally substituted; each L is independently absent or comprises a linker group covalently joining D and Y; and each D is a payload molecule.
• [EN] LINKER-PAYLOAD MOLECULE CONJUGATES<br/>[FR] CONJUGUÉS CONSTITUÉS DE MOLÉCULES DE CHARGE UTILE ET DE LIEURS
  申请人：GLYKOS FINLAND OY

  公开号：WO2014096551A1

  公开（公告）日：2014-06-26

  The invention relates to novel linker-payload molecule conjugates. The invention also relates to novel cell binder-linker-payload molecule conjugates, in particular antibdy conjugates of dolastatin or auristatin derivatives.